Dual trajectories of serum brain-derived neurotrophic factor and cognitive function in people living with HIV

Dual trajectories of serum brain-derived neurotrophic factor and cognitive function in people living with HIV

Abstract This study aimed to identify the interrelationships between mature BDNF (mBDNF), precursor BDNF (proBDNF) trajectories, and cognitive performance in individuals with HIV from sub-Saharan Africa over 96 weeks following antiretroviral therapy (ART) initiation. Using data from 154 participants...

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Bibliographic Details
Main Authors: Henry Ukachukwu Michael, Antony M Rapulana, Theresa Smit, Njabulo Xulu, Sivapragashini Danaviah, Suvira Ramlall, Frasia Oosthuizen
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
HIV/AIDS
Cognition
Brain-derived neurotrophic factor
Group-based trajectory modelling
sub-Saharan Africa
Online Access:https://doi.org/10.1038/s41598-025-99569-6
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https://doi.org/10.1038/s41598-025-99569-6

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