An Unusual Initial Presentation of Lupus Nephritis as a Renal Mass
Lupus nephritis is a frequent manifestation of systemic lupus erythematous. Lupus nephritis usually presents with abnormal urinalysis, proteinuria, and/or renal insufficiency. We report a case of a 48-year-old woman who underwent partial nephrectomy for a fortuitously discovered solid enhancing left...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2015/231974 |
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| author | Remi Goupil Annie-Claire Nadeau-Fredette Virginie Royal Alexandre Dugas Jean-Philippe Lafrance |
| author_facet | Remi Goupil Annie-Claire Nadeau-Fredette Virginie Royal Alexandre Dugas Jean-Philippe Lafrance |
| author_sort | Remi Goupil |
| collection | DOAJ |
| description | Lupus nephritis is a frequent manifestation of systemic lupus erythematous. Lupus nephritis usually presents with abnormal urinalysis, proteinuria, and/or renal insufficiency. We report a case of a 48-year-old woman who underwent partial nephrectomy for a fortuitously discovered solid enhancing left kidney mass. No neoplastic cells were found in the biopsy specimen; however, the pathology findings were compatible with immune complex glomerulonephritis with a predominantly membranous distribution, a pattern suggestive of lupus nephritis. The mass effect was apparently due to a dense interstitial lymphocytic infiltrate resulting in a pseudotumor. Further investigation revealed microscopic hematuria with a normal kidney function and no significant proteinuria. Antinuclear antibodies were negative, although anti-DNA and anti-SSA/Rho antibodies were positive. A diagnosis of probable silent lupus nephritis was made and the patient was followed up without immunosuppressive treatment. After two years of follow-up, she did not progress to overt disease. To our knowledge, this represents the first case of lupus nephritis with an initial presentation as a renal mass. |
| format | Article |
| id | doaj-art-a442e2934db8421eb96f3bf5197b57ab |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-a442e2934db8421eb96f3bf5197b57ab2025-02-03T01:21:07ZengWileyCase Reports in Nephrology2090-66412090-665X2015-01-01201510.1155/2015/231974231974An Unusual Initial Presentation of Lupus Nephritis as a Renal MassRemi Goupil0Annie-Claire Nadeau-Fredette1Virginie Royal2Alexandre Dugas3Jean-Philippe Lafrance4Nephrology Division, Hôpital Maisonneuve-Rosemont, Montreal, QC, H1T 2M4, CanadaNephrology Division, Hôpital Maisonneuve-Rosemont, Montreal, QC, H1T 2M4, CanadaPathology Department, Hôpital Maisonneuve-Rosemont, Montreal, QC, H1T 2M4, CanadaRadiology Division, Hôpital Maisonneuve-Rosemont, Montreal, QC, H1T 2M4, CanadaNephrology Division, Hôpital Maisonneuve-Rosemont, Montreal, QC, H1T 2M4, CanadaLupus nephritis is a frequent manifestation of systemic lupus erythematous. Lupus nephritis usually presents with abnormal urinalysis, proteinuria, and/or renal insufficiency. We report a case of a 48-year-old woman who underwent partial nephrectomy for a fortuitously discovered solid enhancing left kidney mass. No neoplastic cells were found in the biopsy specimen; however, the pathology findings were compatible with immune complex glomerulonephritis with a predominantly membranous distribution, a pattern suggestive of lupus nephritis. The mass effect was apparently due to a dense interstitial lymphocytic infiltrate resulting in a pseudotumor. Further investigation revealed microscopic hematuria with a normal kidney function and no significant proteinuria. Antinuclear antibodies were negative, although anti-DNA and anti-SSA/Rho antibodies were positive. A diagnosis of probable silent lupus nephritis was made and the patient was followed up without immunosuppressive treatment. After two years of follow-up, she did not progress to overt disease. To our knowledge, this represents the first case of lupus nephritis with an initial presentation as a renal mass.http://dx.doi.org/10.1155/2015/231974 |
| spellingShingle | Remi Goupil Annie-Claire Nadeau-Fredette Virginie Royal Alexandre Dugas Jean-Philippe Lafrance An Unusual Initial Presentation of Lupus Nephritis as a Renal Mass Case Reports in Nephrology |
| title | An Unusual Initial Presentation of Lupus Nephritis as a Renal Mass |
| title_full | An Unusual Initial Presentation of Lupus Nephritis as a Renal Mass |
| title_fullStr | An Unusual Initial Presentation of Lupus Nephritis as a Renal Mass |
| title_full_unstemmed | An Unusual Initial Presentation of Lupus Nephritis as a Renal Mass |
| title_short | An Unusual Initial Presentation of Lupus Nephritis as a Renal Mass |
| title_sort | unusual initial presentation of lupus nephritis as a renal mass |
| url | http://dx.doi.org/10.1155/2015/231974 |
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