Characterization of LY3324954 a long-acting glucagon-receptor agonist

Characterization of LY3324954 a long-acting glucagon-receptor agonist

Objective: Glucagon is a crucial regulator of glucose and lipid metabolism as well as whole-body energy balance. Thus, modulation of glucagon receptor (GCGR) activity in the context of single-molecule multi-receptor co-agonists has become an emerging therapeutic target against obesity and obesity-as...

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Main Authors: William Roell, Tamer Coskun, Teayoun Kim, Libbey O’Farrell, Jennifer A. Martin, Shelly Nason, Jasmin Hernandez-Alamillo, Saidharshana Dhantu, Daniel J. Drucker, Kyle W. Sloop, James P. Steele, Jorge Alsina-Fernandez, Kirk M. Habegger
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Molecular Metabolism
Subjects:
Glucagon
Insulin secretion
Glucose homeostasis
Diabetes
Obesity
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877824002047
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