Distribution and functional significance of KLF15 in mouse cerebellum
Abstract Kruppel-like factor 15 (KLF15), a member of the KLF family, is closely involved in many biological processes. However, the mechanism by which KLF15 regulates neural development is still unclear. Considering the complexity and importance of neural network development, in this study, we inves...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Molecular Brain |
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| Online Access: | https://doi.org/10.1186/s13041-025-01172-3 |
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| author | Dan Li Shuijing Cao Yanrong Chen Yueyan Liu Kugeng Huo Zhuangqi Shi Shuxin Han Liecheng Wang |
| author_facet | Dan Li Shuijing Cao Yanrong Chen Yueyan Liu Kugeng Huo Zhuangqi Shi Shuxin Han Liecheng Wang |
| author_sort | Dan Li |
| collection | DOAJ |
| description | Abstract Kruppel-like factor 15 (KLF15), a member of the KLF family, is closely involved in many biological processes. However, the mechanism by which KLF15 regulates neural development is still unclear. Considering the complexity and importance of neural network development, in this study, we investigated the potent regulatory role of KLF15 in neural network development. KLF15 was detected highly expressed in the cerebellum and enriched in Purkinje cells, with a significant increase in KLF15 expression between 15 and 20 days of neural development. Knockdown of KLF15 led to loss of Purkinje cells and impaired motility in mice. Therefore, our study aims to elucidate the relationship between KLF15 and Purkinje cells in mice, may provide a new research idea for the developmental mechanism of the mouse cerebellum. |
| format | Article |
| id | doaj-art-a41a7489105840d6ac039fc1649ed835 |
| institution | Kabale University |
| issn | 1756-6606 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Brain |
| spelling | doaj-art-a41a7489105840d6ac039fc1649ed8352025-01-26T12:58:07ZengBMCMolecular Brain1756-66062025-01-0118111210.1186/s13041-025-01172-3Distribution and functional significance of KLF15 in mouse cerebellumDan Li0Shuijing Cao1Yanrong Chen2Yueyan Liu3Kugeng Huo4Zhuangqi Shi5Shuxin Han6Liecheng Wang7Department of Physiology, School of Basic Medical Sciences, Anhui Medical UniversityDepartment of Physiology, School of Basic Medical Sciences, Anhui Medical UniversityDepartment of Physiology, School of Basic Medical Sciences, Anhui Medical UniversityDepartment of Basic Medicine, Department of Clinical Medicine, West Anhui Health Vocational CollegeCyagen Biosciences (Guangzhou) Inc.Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang UniversityXinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang UniversityDepartment of Physiology, School of Basic Medical Sciences, Anhui Medical UniversityAbstract Kruppel-like factor 15 (KLF15), a member of the KLF family, is closely involved in many biological processes. However, the mechanism by which KLF15 regulates neural development is still unclear. Considering the complexity and importance of neural network development, in this study, we investigated the potent regulatory role of KLF15 in neural network development. KLF15 was detected highly expressed in the cerebellum and enriched in Purkinje cells, with a significant increase in KLF15 expression between 15 and 20 days of neural development. Knockdown of KLF15 led to loss of Purkinje cells and impaired motility in mice. Therefore, our study aims to elucidate the relationship between KLF15 and Purkinje cells in mice, may provide a new research idea for the developmental mechanism of the mouse cerebellum.https://doi.org/10.1186/s13041-025-01172-3KLF15Transcription factorCerebellumPurkinje cellsNeural developmentAtaxia |
| spellingShingle | Dan Li Shuijing Cao Yanrong Chen Yueyan Liu Kugeng Huo Zhuangqi Shi Shuxin Han Liecheng Wang Distribution and functional significance of KLF15 in mouse cerebellum Molecular Brain KLF15 Transcription factor Cerebellum Purkinje cells Neural development Ataxia |
| title | Distribution and functional significance of KLF15 in mouse cerebellum |
| title_full | Distribution and functional significance of KLF15 in mouse cerebellum |
| title_fullStr | Distribution and functional significance of KLF15 in mouse cerebellum |
| title_full_unstemmed | Distribution and functional significance of KLF15 in mouse cerebellum |
| title_short | Distribution and functional significance of KLF15 in mouse cerebellum |
| title_sort | distribution and functional significance of klf15 in mouse cerebellum |
| topic | KLF15 Transcription factor Cerebellum Purkinje cells Neural development Ataxia |
| url | https://doi.org/10.1186/s13041-025-01172-3 |
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