NF-κB signaling and the tumor microenvironment in osteosarcoma: implications for immune evasion and therapeutic resistance

NF-κB signaling and the tumor microenvironment in osteosarcoma: implications for immune evasion and therapeutic resistance

Osteosarcoma, a highly aggressive malignancy with a generally poor prognosis, is characterized by tumor cells’ ability to evade immune responses and resist treatment. The nuclear transcription factor NF-κB signaling pathway is crucial in regulating inflammatory and immune reactions. It occupies a ce...

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Bibliographic Details
Main Authors: Shaoyan Shi, Xuehai Ou, Chao Liu, Rui Li, Qianjin Zheng, Leiming Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
osteosarcoma
NF-κB signaling
tumor microenvironment
immune evasion and
malignant bone tumor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1518664/full
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