NF-κB signaling and the tumor microenvironment in osteosarcoma: implications for immune evasion and therapeutic resistance
Osteosarcoma, a highly aggressive malignancy with a generally poor prognosis, is characterized by tumor cells’ ability to evade immune responses and resist treatment. The nuclear transcription factor NF-κB signaling pathway is crucial in regulating inflammatory and immune reactions. It occupies a ce...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1518664/full |
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| author | Shaoyan Shi Xuehai Ou Chao Liu Rui Li Qianjin Zheng Leiming Hu |
| author_facet | Shaoyan Shi Xuehai Ou Chao Liu Rui Li Qianjin Zheng Leiming Hu |
| author_sort | Shaoyan Shi |
| collection | DOAJ |
| description | Osteosarcoma, a highly aggressive malignancy with a generally poor prognosis, is characterized by tumor cells’ ability to evade immune responses and resist treatment. The nuclear transcription factor NF-κB signaling pathway is crucial in regulating inflammatory and immune reactions. It occupies a central position in the development of the osteosarcoma tumor microenvironment. This research aimed to explore how NF-κB influences the recruitment and polarization of tumor-associated macrophages and myeloid-derived suppressor cells, both of which contribute to immunosuppression. Furthermore, NF-κB facilitates immune surveillance evasion in osteosarcoma cells by altering the expression of immune checkpoint molecules, such as PD-L1. It also enhances tumor cell resistance to chemotherapy and radiotherapy by activating anti-apoptotic signaling pathways and exacerbating treatment-induced inflammation. Potential therapeutic approaches include using NF-κB inhibitors, possibly in combination with immune checkpoint inhibitors, to overcome tumor cell resistance mechanisms and reshape antitumor immune responses. A thorough examination of NF-κB’s role in osteosarcoma development is expected to yield novel clinical treatment strategies, and significantly improve patient prognosis by targeting this key signaling pathway. |
| format | Article |
| id | doaj-art-a416d5e3ff284ff9ae2b67dfae8ebc56 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-a416d5e3ff284ff9ae2b67dfae8ebc562025-01-30T06:22:43ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011610.3389/fimmu.2025.15186641518664NF-κB signaling and the tumor microenvironment in osteosarcoma: implications for immune evasion and therapeutic resistanceShaoyan ShiXuehai OuChao LiuRui LiQianjin ZhengLeiming HuOsteosarcoma, a highly aggressive malignancy with a generally poor prognosis, is characterized by tumor cells’ ability to evade immune responses and resist treatment. The nuclear transcription factor NF-κB signaling pathway is crucial in regulating inflammatory and immune reactions. It occupies a central position in the development of the osteosarcoma tumor microenvironment. This research aimed to explore how NF-κB influences the recruitment and polarization of tumor-associated macrophages and myeloid-derived suppressor cells, both of which contribute to immunosuppression. Furthermore, NF-κB facilitates immune surveillance evasion in osteosarcoma cells by altering the expression of immune checkpoint molecules, such as PD-L1. It also enhances tumor cell resistance to chemotherapy and radiotherapy by activating anti-apoptotic signaling pathways and exacerbating treatment-induced inflammation. Potential therapeutic approaches include using NF-κB inhibitors, possibly in combination with immune checkpoint inhibitors, to overcome tumor cell resistance mechanisms and reshape antitumor immune responses. A thorough examination of NF-κB’s role in osteosarcoma development is expected to yield novel clinical treatment strategies, and significantly improve patient prognosis by targeting this key signaling pathway.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1518664/fullosteosarcomaNF-κB signalingtumor microenvironmentimmune evasion andmalignant bone tumor |
| spellingShingle | Shaoyan Shi Xuehai Ou Chao Liu Rui Li Qianjin Zheng Leiming Hu NF-κB signaling and the tumor microenvironment in osteosarcoma: implications for immune evasion and therapeutic resistance Frontiers in Immunology osteosarcoma NF-κB signaling tumor microenvironment immune evasion and malignant bone tumor |
| title | NF-κB signaling and the tumor microenvironment in osteosarcoma: implications for immune evasion and therapeutic resistance |
| title_full | NF-κB signaling and the tumor microenvironment in osteosarcoma: implications for immune evasion and therapeutic resistance |
| title_fullStr | NF-κB signaling and the tumor microenvironment in osteosarcoma: implications for immune evasion and therapeutic resistance |
| title_full_unstemmed | NF-κB signaling and the tumor microenvironment in osteosarcoma: implications for immune evasion and therapeutic resistance |
| title_short | NF-κB signaling and the tumor microenvironment in osteosarcoma: implications for immune evasion and therapeutic resistance |
| title_sort | nf κb signaling and the tumor microenvironment in osteosarcoma implications for immune evasion and therapeutic resistance |
| topic | osteosarcoma NF-κB signaling tumor microenvironment immune evasion and malignant bone tumor |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1518664/full |
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