Palmitoylation-related gene ZDHHC22 as a potential diagnostic and immunomodulatory target in Alzheimer’s disease: insights from machine learning analyses and WGCNA

Palmitoylation-related gene ZDHHC22 as a potential diagnostic and immunomodulatory target in Alzheimer’s disease: insights from machine learning analyses and WGCNA

Abstract Background The mechanism of palmitoylation in the pathogenesis of Alzheimer's disease (AD) remains unclear. Methods This study retrieved AD data sets from the GEO database to identify palmitoylation-associated genes (PRGs). This study applied WGCNA along with three machine learning alg...

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Bibliographic Details
Main Authors: Sanying Mao, Xiyao Zhao, Lei Wang, Yilong Man, Kaiyuan Li
Format: Article
Language:English
Published: BMC 2025-01-01
Series:European Journal of Medical Research
Subjects:
Alzheimer’s disease
Palmitoylation
Machine learning
Weighted gene co-expression network analysis
Immunomodulatory
Online Access:https://doi.org/10.1186/s40001-025-02277-0
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https://doi.org/10.1186/s40001-025-02277-0

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