Supervised and unsupervised deep learning-based approaches for studying DNA replication spatiotemporal dynamics

Abstract In eukaryotic cells, DNA replication is organised both spatially and temporally, as evidenced by the stage-specific spatial distribution of replication foci in the nucleus. Despite the genetic association of aberrant DNA replication with numerous human diseases, the labour-intensive methods...

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Bibliographic Details
Main Authors: Julian Ng-Kee-Kwong, Ben Philps, Fiona N. C. Smith, Aleksandra Sobieska, Naiming Chen, Constance Alabert, Hakan Bilen, Sara C. B. Buonomo
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07744-2
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