Dapagliflozin in Chronic Kidney Disease: Insights from Network Pharmacology and Molecular Docking Simulation

Dapagliflozin in Chronic Kidney Disease: Insights from Network Pharmacology and Molecular Docking Simulation

Chronic kidney disease (CKD) involves inflammation, oxidative stress, and fibrosis, leading to renal dysfunction. Dapagliflozin, an SGLT2 inhibitor, shows renoprotective effects beyond glucose control, but its precise molecular mechanisms remain unclear. This study utilizes network pharmacology and...

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Bibliographic Details
Main Authors:	Atthaphong Phongphithakchai, Aman Tedasen, Ratana Netphakdee, Rattana Leelawattana, Thatsaphan Srithongkul, Sukit Raksasuk, Jason C. Huang, Moragot Chatatikun
Format:	Article
Language:	English
Published:	MDPI AG 2025-03-01
Series:	Life
Subjects:	dapagliflozin chronic kidney disease network pharmacology molecular docking protein-protein interaction
Online Access:	https://www.mdpi.com/2075-1729/15/3/437
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