Mucosal Immunization with an Influenza Vector Carrying SARS-CoV-2 N Protein Protects Naïve Mice and Prevents Disease Enhancement in Seropositive Th2-Prone Mice

Mucosal Immunization with an Influenza Vector Carrying SARS-CoV-2 N Protein Protects Naïve Mice and Prevents Disease Enhancement in Seropositive Th2-Prone Mice

<b>Background/Objectives:</b> Intranasal vaccination enhances protection against respiratory viruses by providing stimuli to the immune system at the primary site of infection, promoting a balanced and effective response. Influenza vectors with truncated NS1 are a promising vaccine appro...

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Main Authors: Mariia V. Sergeeva, Kirill Vasilev, Ekaterina Romanovskaya-Romanko, Nikita Yolshin, Anastasia Pulkina, Daria Shamakova, Anna-Polina Shurygina, Arman Muzhikyan, Dmitry Lioznov, Marina Stukova
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Vaccines
Subjects:
influenza vector
mucosal vaccine
SARS-CoV-2
inactivated vaccine
VAERD
Online Access:https://www.mdpi.com/2076-393X/13/1/15
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