Scavenger receptor class B type I knockout mice develop extensive diet-induced coronary artery atherosclerosis in an age-dependent manner.

Scavenger receptor class B type I knockout mice develop extensive diet-induced coronary artery atherosclerosis in an age-dependent manner.

<h4>Objective</h4>Homozygous knockout of scavenger receptor class B type I (SR-B1) in mice with atherogenic mutations (such as knockout of the apolipoprotein E or low density lipoprotein receptor genes) results in spontaneous or diet-induced coronary heart disease characterized by athero...

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Main Authors: Samuel K Lee, Ting Xiong, Alexander S Qian, Jeong-Ah Yoo, B Sumayyah H Sokeechand, Mark T Fuller, Peter L Gross, Richard C Austin, Suleiman A Igdoura, Bernardo L Trigatti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0318118
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https://doi.org/10.1371/journal.pone.0318118

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