Characteristics, Mortality, and Clinical Outcomes of Hospitalized Patients with COVID-19 and Diabetes: A Reference Single-Center Cohort Study from Poland
Background. Diabetes is a risk factor for a severe course of COVID-19. We evaluated the characteristics and risk factors associated with undesirable outcomes in diabetic patients (DPs) hospitalized due to COVID-19. Materials and Methods. The data analysis of patients admitted between March 6, 2020,...
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Wiley
2023-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2023/8700302 |
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| author | Michał Kania Konrad Mazur Michał Terlecki Bartłomiej Matejko Jerzy Hohendorff Zlata Chaykivska Mateusz Fiema Marianna Kopka Małgorzata Kostrzycka Magdalena Wilk Tomasz Klupa Przemysław Witek Barbara Katra Marek Klocek Marek Rajzer Maciej T. Malecki |
| author_facet | Michał Kania Konrad Mazur Michał Terlecki Bartłomiej Matejko Jerzy Hohendorff Zlata Chaykivska Mateusz Fiema Marianna Kopka Małgorzata Kostrzycka Magdalena Wilk Tomasz Klupa Przemysław Witek Barbara Katra Marek Klocek Marek Rajzer Maciej T. Malecki |
| author_sort | Michał Kania |
| collection | DOAJ |
| description | Background. Diabetes is a risk factor for a severe course of COVID-19. We evaluated the characteristics and risk factors associated with undesirable outcomes in diabetic patients (DPs) hospitalized due to COVID-19. Materials and Methods. The data analysis of patients admitted between March 6, 2020, and May 31, 2021, to the University Hospital in Krakow (Poland), a reference center for COVID-19, was performed. The data were gathered from their medical records. Results. A total number of 5191 patients were included, of which 2348 (45.2%) were women. The patients were at the median age of 64 (IQR: 51–74) years, and 1364 (26.3%) were DPs. DPs, compared to nondiabetics, were older (median age: 70 years, IQR: 62–77 vs. 62, IQR: 47–72, and p < 0.001) and had a similar gender distribution. The DP group had a higher mortality rate (26.2% vs. 15.7%, p < 0.001) and longer hospital stays (median: 15 days, IQR: 10–24 vs. 13, IQR: 9–20, and p < 0.001). DPs were admitted to the ICU more frequently (15.7% vs. 11.0%, p < 0.001) and required mechanical ventilation more often (15.5% vs. 11.3%, p < 0.001). In a multivariate logistic regression, factors associated with a higher risk of death were age >65 years, glycaemia >10 mmol/L, CRP and D-dimer level, prehospital insulin and loop diuretic use, presence of heart failure, and chronic kidney disease. Factors contributing to lower mortality were in-hospital use of statin, thiazide diuretic, and calcium channel blocker. Conclusion. In this large COVID-19 cohort, DPs constituted more than a quarter of hospitalized patients. The risk of death and other outcomes compared to nondiabetics was higher in this group. We identified a number of clinical, laboratory, and therapeutic variables associated with the risk of hospital death in DPs. |
| format | Article |
| id | doaj-art-a3b2e3f7205d45359a55b207b3629fb7 |
| institution | Kabale University |
| issn | 1687-8345 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
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| series | International Journal of Endocrinology |
| spelling | doaj-art-a3b2e3f7205d45359a55b207b3629fb72025-02-03T06:12:58ZengWileyInternational Journal of Endocrinology1687-83452023-01-01202310.1155/2023/8700302Characteristics, Mortality, and Clinical Outcomes of Hospitalized Patients with COVID-19 and Diabetes: A Reference Single-Center Cohort Study from PolandMichał Kania0Konrad Mazur1Michał Terlecki2Bartłomiej Matejko3Jerzy Hohendorff4Zlata Chaykivska5Mateusz Fiema6Marianna Kopka7Małgorzata Kostrzycka8Magdalena Wilk9Tomasz Klupa10Przemysław Witek11Barbara Katra12Marek Klocek13Marek Rajzer14Maciej T. Malecki15Department of Metabolic Diseases and DiabetologyUniversity Hospital in KrakowUniversity Hospital in KrakowDepartment of Metabolic Diseases and DiabetologyDepartment of Metabolic Diseases and DiabetologyUniversity Hospital in KrakowUniversity Hospital in KrakowUniversity Hospital in KrakowUniversity Hospital in KrakowDepartment of Metabolic Diseases and DiabetologyDepartment of Metabolic Diseases and DiabetologyDepartment of Metabolic Diseases and DiabetologyDepartment of Metabolic Diseases and DiabetologyUniversity Hospital in KrakowUniversity Hospital in KrakowDepartment of Metabolic Diseases and DiabetologyBackground. Diabetes is a risk factor for a severe course of COVID-19. We evaluated the characteristics and risk factors associated with undesirable outcomes in diabetic patients (DPs) hospitalized due to COVID-19. Materials and Methods. The data analysis of patients admitted between March 6, 2020, and May 31, 2021, to the University Hospital in Krakow (Poland), a reference center for COVID-19, was performed. The data were gathered from their medical records. Results. A total number of 5191 patients were included, of which 2348 (45.2%) were women. The patients were at the median age of 64 (IQR: 51–74) years, and 1364 (26.3%) were DPs. DPs, compared to nondiabetics, were older (median age: 70 years, IQR: 62–77 vs. 62, IQR: 47–72, and p < 0.001) and had a similar gender distribution. The DP group had a higher mortality rate (26.2% vs. 15.7%, p < 0.001) and longer hospital stays (median: 15 days, IQR: 10–24 vs. 13, IQR: 9–20, and p < 0.001). DPs were admitted to the ICU more frequently (15.7% vs. 11.0%, p < 0.001) and required mechanical ventilation more often (15.5% vs. 11.3%, p < 0.001). In a multivariate logistic regression, factors associated with a higher risk of death were age >65 years, glycaemia >10 mmol/L, CRP and D-dimer level, prehospital insulin and loop diuretic use, presence of heart failure, and chronic kidney disease. Factors contributing to lower mortality were in-hospital use of statin, thiazide diuretic, and calcium channel blocker. Conclusion. In this large COVID-19 cohort, DPs constituted more than a quarter of hospitalized patients. The risk of death and other outcomes compared to nondiabetics was higher in this group. We identified a number of clinical, laboratory, and therapeutic variables associated with the risk of hospital death in DPs.http://dx.doi.org/10.1155/2023/8700302 |
| spellingShingle | Michał Kania Konrad Mazur Michał Terlecki Bartłomiej Matejko Jerzy Hohendorff Zlata Chaykivska Mateusz Fiema Marianna Kopka Małgorzata Kostrzycka Magdalena Wilk Tomasz Klupa Przemysław Witek Barbara Katra Marek Klocek Marek Rajzer Maciej T. Malecki Characteristics, Mortality, and Clinical Outcomes of Hospitalized Patients with COVID-19 and Diabetes: A Reference Single-Center Cohort Study from Poland International Journal of Endocrinology |
| title | Characteristics, Mortality, and Clinical Outcomes of Hospitalized Patients with COVID-19 and Diabetes: A Reference Single-Center Cohort Study from Poland |
| title_full | Characteristics, Mortality, and Clinical Outcomes of Hospitalized Patients with COVID-19 and Diabetes: A Reference Single-Center Cohort Study from Poland |
| title_fullStr | Characteristics, Mortality, and Clinical Outcomes of Hospitalized Patients with COVID-19 and Diabetes: A Reference Single-Center Cohort Study from Poland |
| title_full_unstemmed | Characteristics, Mortality, and Clinical Outcomes of Hospitalized Patients with COVID-19 and Diabetes: A Reference Single-Center Cohort Study from Poland |
| title_short | Characteristics, Mortality, and Clinical Outcomes of Hospitalized Patients with COVID-19 and Diabetes: A Reference Single-Center Cohort Study from Poland |
| title_sort | characteristics mortality and clinical outcomes of hospitalized patients with covid 19 and diabetes a reference single center cohort study from poland |
| url | http://dx.doi.org/10.1155/2023/8700302 |
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