The contribution of different polyphenol compositions from chokeberry produced in China to cellular antioxidant and antiproliferative activities
Abundant polyphenols make chokeberry have beneficial antioxidant and antiproliferative activity. In order to explore the contribution of different polyphenols in chokeberry to these activities, this study was conducted to determine polyphenol composition from 7 chokeberry varieties produced in China...
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Tsinghua University Press
2023-09-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453023000186 |
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| author | Ningxuan Gao Xu Si Wenzhong Han Ersheng Gong Chi Shu Jinlong Tian Yuehua Wang Jiyue Zhang Binxu Li Bin Li |
| author_facet | Ningxuan Gao Xu Si Wenzhong Han Ersheng Gong Chi Shu Jinlong Tian Yuehua Wang Jiyue Zhang Binxu Li Bin Li |
| author_sort | Ningxuan Gao |
| collection | DOAJ |
| description | Abundant polyphenols make chokeberry have beneficial antioxidant and antiproliferative activity. In order to explore the contribution of different polyphenols in chokeberry to these activities, this study was conducted to determine polyphenol composition from 7 chokeberry varieties produced in China. Totally, 11 kinds of main polyphenol monomers were identified and quantified by UPLC-Q-TOF-MS and UPLC-PDA. HepG2 cells were used to evaluate their cellular antioxidant and antiproliferative activities. Partial least squares method was utilized to analyze multivariate correlations between proportion of different composition and monomers in total polyphenols with these activities. The results showed that the highest proportion in chokeberry polyphenols was proanthocyanidins. In comparing the bioactivities of 7 varieties of chokeberry, ‘Viking’ and purple chokeberry had the strongest antioxidant activity, while ‘Fukangyuan 1#’ had the strongest antiproliferative activity. In terms of the contribution sources of these bioactivities, the total antioxidant activity of chokeberry mainly depended on the contribution of free polyphenols. As the main source of cellular antioxidant activity, anthocyanins and neochlorogenic acid can provide more contribution. The antiproliferative activity mainly depended on the proportion of free polyphenols and proanthocyanidins in total polyphenols. The results may provide some new possibilities for the comprehensive utilization of polyphenols from chokeberry. |
| format | Article |
| id | doaj-art-a3adf90a07364e2bb1cb70c4a1ab13a6 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-a3adf90a07364e2bb1cb70c4a1ab13a62025-02-03T05:40:25ZengTsinghua University PressFood Science and Human Wellness2213-45302023-09-0112515901600The contribution of different polyphenol compositions from chokeberry produced in China to cellular antioxidant and antiproliferative activitiesNingxuan Gao0Xu Si1Wenzhong Han2Ersheng Gong3Chi Shu4Jinlong Tian5Yuehua Wang6Jiyue Zhang7Binxu Li8Bin Li9Department of Food Science, College of Food, Shenyang Agricultural University, Shenyang 110161, China; National R&D Professional Center For Berry Processing, Shenyang 110161, ChinaDepartment of Food Science, College of Food, Shenyang Agricultural University, Shenyang 110161, China; National R&D Professional Center For Berry Processing, Shenyang 110161, ChinaAgriculture and Forest Institute in Arid of Liaoning, Chaoyang 122000, ChinaDepartment of Food Science, College of Food, Shenyang Agricultural University, Shenyang 110161, China; National R&D Professional Center For Berry Processing, Shenyang 110161, ChinaDepartment of Food Science, College of Food, Shenyang Agricultural University, Shenyang 110161, China; National R&D Professional Center For Berry Processing, Shenyang 110161, ChinaDepartment of Food Science, College of Food, Shenyang Agricultural University, Shenyang 110161, China; National R&D Professional Center For Berry Processing, Shenyang 110161, ChinaDepartment of Food Science, College of Food, Shenyang Agricultural University, Shenyang 110161, China; National R&D Professional Center For Berry Processing, Shenyang 110161, ChinaDepartment of Food Science, College of Food, Shenyang Agricultural University, Shenyang 110161, China; National R&D Professional Center For Berry Processing, Shenyang 110161, ChinaDepartment of Food Science, College of Food, Shenyang Agricultural University, Shenyang 110161, China; National R&D Professional Center For Berry Processing, Shenyang 110161, ChinaDepartment of Food Science, College of Food, Shenyang Agricultural University, Shenyang 110161, China; National R&D Professional Center For Berry Processing, Shenyang 110161, China; Corresponding author at: Department of Food Science, College of Food, Shenyang Agricultural University, Shenyang 110161, China.Abundant polyphenols make chokeberry have beneficial antioxidant and antiproliferative activity. In order to explore the contribution of different polyphenols in chokeberry to these activities, this study was conducted to determine polyphenol composition from 7 chokeberry varieties produced in China. Totally, 11 kinds of main polyphenol monomers were identified and quantified by UPLC-Q-TOF-MS and UPLC-PDA. HepG2 cells were used to evaluate their cellular antioxidant and antiproliferative activities. Partial least squares method was utilized to analyze multivariate correlations between proportion of different composition and monomers in total polyphenols with these activities. The results showed that the highest proportion in chokeberry polyphenols was proanthocyanidins. In comparing the bioactivities of 7 varieties of chokeberry, ‘Viking’ and purple chokeberry had the strongest antioxidant activity, while ‘Fukangyuan 1#’ had the strongest antiproliferative activity. In terms of the contribution sources of these bioactivities, the total antioxidant activity of chokeberry mainly depended on the contribution of free polyphenols. As the main source of cellular antioxidant activity, anthocyanins and neochlorogenic acid can provide more contribution. The antiproliferative activity mainly depended on the proportion of free polyphenols and proanthocyanidins in total polyphenols. The results may provide some new possibilities for the comprehensive utilization of polyphenols from chokeberry.http://www.sciencedirect.com/science/article/pii/S2213453023000186ChokeberryAnthocyaninsProanthocyanidinsAntioxidant;Antiproliferation |
| spellingShingle | Ningxuan Gao Xu Si Wenzhong Han Ersheng Gong Chi Shu Jinlong Tian Yuehua Wang Jiyue Zhang Binxu Li Bin Li The contribution of different polyphenol compositions from chokeberry produced in China to cellular antioxidant and antiproliferative activities Food Science and Human Wellness Chokeberry Anthocyanins Proanthocyanidins Antioxidant; Antiproliferation |
| title | The contribution of different polyphenol compositions from chokeberry produced in China to cellular antioxidant and antiproliferative activities |
| title_full | The contribution of different polyphenol compositions from chokeberry produced in China to cellular antioxidant and antiproliferative activities |
| title_fullStr | The contribution of different polyphenol compositions from chokeberry produced in China to cellular antioxidant and antiproliferative activities |
| title_full_unstemmed | The contribution of different polyphenol compositions from chokeberry produced in China to cellular antioxidant and antiproliferative activities |
| title_short | The contribution of different polyphenol compositions from chokeberry produced in China to cellular antioxidant and antiproliferative activities |
| title_sort | contribution of different polyphenol compositions from chokeberry produced in china to cellular antioxidant and antiproliferative activities |
| topic | Chokeberry Anthocyanins Proanthocyanidins Antioxidant; Antiproliferation |
| url | http://www.sciencedirect.com/science/article/pii/S2213453023000186 |
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