A New Process for the Synthesis of Budesonide 21-Phosphate and Evaluation in a Murine Model of Inflammation

A New Process for the Synthesis of Budesonide 21-Phosphate and Evaluation in a Murine Model of Inflammation

In this study, a new and straightforward process for the preparation of budesonide 21-phosphate (Bud-21P) and its disodium salt (Bud-21P-Na2) is described. The method results in a yield comparable to those obtained by diphosphoryl chloride, but it is more manageable, less expensive, and safer. The n...

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Main Authors: Angela Corvino, Elisabetta Granato, Antonia Scognamiglio, Ferdinando Fiorino, Francesco Frecentese, Elisa Magli, Elisa Perissutti, Vincenzo Santagada, Giuseppe Cirino, Ida Cerqua, Rocco Pavese, Antonio Petti, Francesca Pavese, Francesco Petti, Fiorentina Roviezzo, Beatrice Severino, Giuseppe Caliendo
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Molecules
Subjects:
anti-inflammatory drugs
inhaled corticosteroids
inflammation
phosphorylation
Online Access:https://www.mdpi.com/1420-3049/29/18/4514
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