Wilms tumor primary cultures capture phenotypic heterogeneity and facilitate preclinical screening

Wilms tumor primary cultures capture phenotypic heterogeneity and facilitate preclinical screening

Wilms tumors (WT) are characterized by variable contributions of blastemal, epithelial and stromal elements, reflecting their diverse cellular origins and genetic drivers. In vitro models remain rare, despite a growing need to better characterize tumor biology and evaluate new treatments. Using thre...

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Bibliographic Details
Main Authors: Lisa Götz, Jenny Wegert, Alireza Paikari, Silke Appenzeller, Sabrina Bausenwein, Christian Vokuhl, Taryn D. Treger, Jarno Drost, Christin Linderkamp, Dominik T. Schneider, Karen Ernestus, Steven W. Warman, Jörg Fuchs, Nils Welter, Norbert Graf, Sam Behjati, Rhoikos Furtwängler, Manfred Gessler
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Translational Oncology
Subjects:
Wilms tumor
Nephroblastoma
Organoid culture
Drug screening
MYCN
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523324003899
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