Aggrecan protects against plaque accumulation and is essential for proper microglial responses to plaques

Aggrecan protects against plaque accumulation and is essential for proper microglial responses to plaques

Summary: Alzheimer’s disease (AD) is a neurodegenerative disease characterized by amyloid plaques and neurofibrillary tangles. Recent evidence implicates extracellular matrix (ECM) dysfunction in disease pathogenesis, including extensive loss of perineuronal nets (PNNs). PNNs are neuron-ensheathing...

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Main Authors: Rocio A. Barahona, Nellie E. Kwang, Aashna R. Kono-Soosaipillai, Giovanna Rubio Salgado, Kristine M. Tran, Yueh-Hao Lu, Siddharth Reddy, Celia da Cunha, Eric Velazquez-Rivera, Joshua D. Crapser, Xiangmin Xu, Lindsay A. Hohsfield, Kim N. Green
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Reports
Subjects:
CP: Neuroscience
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725008356
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http://www.sciencedirect.com/science/article/pii/S2211124725008356

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