Cyclooxygenase-1 deletion in 5 × FAD mice protects against microglia-induced neuroinflammation and mitigates cognitive impairment

Cyclooxygenase-1 deletion in 5 × FAD mice protects against microglia-induced neuroinflammation and mitigates cognitive impairment

Abstract Background Alzheimer's disease (AD) is a neurodegenerative disease with major symptoms including memory and learning deficits. Neuroinflammation associated with reactive microglia promotes AD progression. These reactive microglia secrete prostaglandins, which are synthesized through th...

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Main Authors: Jie Wang, Hong Ni, Yu Wang, Luyao Wei, Hanqing Ding, Zhongzhao Guo, Hao Pan, Ying Yu, Jia Luo, Weidong Pan, Deheng Wang, Zun-Ji Ke
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Translational Neurodegeneration
Subjects:
Alzheimer’s disease
Cyclooxygenase-1
Neuroinflammation
Microglia
Cognitive impairment
NLRP3 inflammasome
Online Access:https://doi.org/10.1186/s40035-025-00501-9
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https://doi.org/10.1186/s40035-025-00501-9

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