Automated Subfield Volumetric Analysis of Hippocampus in Patients with Drug-Naïve Nondementia Parkinson’s Disease
Several studies used automated segmentation of hippocampal subfield (ASHS) for detailed measurements of anatomic subregions of the hippocampus, especially in the field of neurodegenerative disorders. In this study, we investigated the hippocampal subfield volume of patients with early-stage nondemen...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2019/8254263 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832553561934790656 |
|---|---|
| author | Jin-Woo Park Chan-Nyoung Lee Youngbo Sim Hyung-Kyu Ham Woo-Suk Tae Byung-Jo Kim |
| author_facet | Jin-Woo Park Chan-Nyoung Lee Youngbo Sim Hyung-Kyu Ham Woo-Suk Tae Byung-Jo Kim |
| author_sort | Jin-Woo Park |
| collection | DOAJ |
| description | Several studies used automated segmentation of hippocampal subfield (ASHS) for detailed measurements of anatomic subregions of the hippocampus, especially in the field of neurodegenerative disorders. In this study, we investigated the hippocampal subfield volume of patients with early-stage nondementia PD compared with normal healthy subjects using the ASHS method. A total of 32 subjects were enrolled in this study (sixteen patients with drug naive nondementia PD and sixteen healthy controls). All subjects were scanned with a 1.5 tesla MRI. The volumes of the seven subfields were calculated separately, and then, the whole hippocampal volume was calculated by the summing of CA1, CA2-3, CA4-DG, subiculum, presubiculum, and fimbria, excluding the hippocampal fissure. There were significant diagnosis-by-hemisphere interactive effects on the total hippocampal volume (F = 5.197; p=0.031) and the subfield volume of CA2-3 (F = 7.586; p=0.010) and CA4-DG (F = 7.403; p=0.011). The volumes of CA2-3 (F = 19.911; p<0.001), CA4-DG (F = 20.273; p<0.001), and total hippocampus (F = 10.573; p=0.005) in the left hemisphere were reduced compared to the right hemisphere. We suggest that the hippocampal volume asymmetry, especially in CA4-DG and CA2-3, could be observed in drug-naïve PD patients even in the early stage of the disease. |
| format | Article |
| id | doaj-art-a3084b64ffb5473c8d4b41820892e984 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-a3084b64ffb5473c8d4b41820892e9842025-02-03T05:53:43ZengWileyParkinson's Disease2090-80832042-00802019-01-01201910.1155/2019/82542638254263Automated Subfield Volumetric Analysis of Hippocampus in Patients with Drug-Naïve Nondementia Parkinson’s DiseaseJin-Woo Park0Chan-Nyoung Lee1Youngbo Sim2Hyung-Kyu Ham3Woo-Suk Tae4Byung-Jo Kim5Department of Clinical Pharmacology and Toxicology, Korea University College of Medicine, Korea University Anam Hospital, Seoul, Republic of KoreaDepartment of Neurology, Korea University College of Medicine, Korea University Anam Hospital, Seoul, Republic of KoreaBrain Convergence Research Center, Korea University, Seoul, Republic of KoreaSaint John’s Preparatory School, Collegeville, MN, USABrain Convergence Research Center, Korea University, Seoul, Republic of KoreaDepartment of Neurology, Korea University College of Medicine, Korea University Anam Hospital, Seoul, Republic of KoreaSeveral studies used automated segmentation of hippocampal subfield (ASHS) for detailed measurements of anatomic subregions of the hippocampus, especially in the field of neurodegenerative disorders. In this study, we investigated the hippocampal subfield volume of patients with early-stage nondementia PD compared with normal healthy subjects using the ASHS method. A total of 32 subjects were enrolled in this study (sixteen patients with drug naive nondementia PD and sixteen healthy controls). All subjects were scanned with a 1.5 tesla MRI. The volumes of the seven subfields were calculated separately, and then, the whole hippocampal volume was calculated by the summing of CA1, CA2-3, CA4-DG, subiculum, presubiculum, and fimbria, excluding the hippocampal fissure. There were significant diagnosis-by-hemisphere interactive effects on the total hippocampal volume (F = 5.197; p=0.031) and the subfield volume of CA2-3 (F = 7.586; p=0.010) and CA4-DG (F = 7.403; p=0.011). The volumes of CA2-3 (F = 19.911; p<0.001), CA4-DG (F = 20.273; p<0.001), and total hippocampus (F = 10.573; p=0.005) in the left hemisphere were reduced compared to the right hemisphere. We suggest that the hippocampal volume asymmetry, especially in CA4-DG and CA2-3, could be observed in drug-naïve PD patients even in the early stage of the disease.http://dx.doi.org/10.1155/2019/8254263 |
| spellingShingle | Jin-Woo Park Chan-Nyoung Lee Youngbo Sim Hyung-Kyu Ham Woo-Suk Tae Byung-Jo Kim Automated Subfield Volumetric Analysis of Hippocampus in Patients with Drug-Naïve Nondementia Parkinson’s Disease Parkinson's Disease |
| title | Automated Subfield Volumetric Analysis of Hippocampus in Patients with Drug-Naïve Nondementia Parkinson’s Disease |
| title_full | Automated Subfield Volumetric Analysis of Hippocampus in Patients with Drug-Naïve Nondementia Parkinson’s Disease |
| title_fullStr | Automated Subfield Volumetric Analysis of Hippocampus in Patients with Drug-Naïve Nondementia Parkinson’s Disease |
| title_full_unstemmed | Automated Subfield Volumetric Analysis of Hippocampus in Patients with Drug-Naïve Nondementia Parkinson’s Disease |
| title_short | Automated Subfield Volumetric Analysis of Hippocampus in Patients with Drug-Naïve Nondementia Parkinson’s Disease |
| title_sort | automated subfield volumetric analysis of hippocampus in patients with drug naive nondementia parkinson s disease |
| url | http://dx.doi.org/10.1155/2019/8254263 |
| work_keys_str_mv | AT jinwoopark automatedsubfieldvolumetricanalysisofhippocampusinpatientswithdrugnaivenondementiaparkinsonsdisease AT channyounglee automatedsubfieldvolumetricanalysisofhippocampusinpatientswithdrugnaivenondementiaparkinsonsdisease AT youngbosim automatedsubfieldvolumetricanalysisofhippocampusinpatientswithdrugnaivenondementiaparkinsonsdisease AT hyungkyuham automatedsubfieldvolumetricanalysisofhippocampusinpatientswithdrugnaivenondementiaparkinsonsdisease AT woosuktae automatedsubfieldvolumetricanalysisofhippocampusinpatientswithdrugnaivenondementiaparkinsonsdisease AT byungjokim automatedsubfieldvolumetricanalysisofhippocampusinpatientswithdrugnaivenondementiaparkinsonsdisease |