Revisiting ABC Transporters and Their Clinical Significance in Glioblastoma

Revisiting ABC Transporters and Their Clinical Significance in Glioblastoma

<b>Background</b>: The multiple drug-resistant phenomenon has long since plagued the effectiveness of various chemotherapies used in the treatment of patients with glioblastoma (GBM), which is still incurable to this day. ATP-binding cassette (ABC) transporters function as drug transport...

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Main Authors: Brandon Wee Siang Phon, Shalini Sundramurthi Chelliah, Dina El-Rabie Osman, Saatheeyavaane Bhuvanendran, Ammu Kutty Radhakrishnan, Muhamad Noor Alfarizal Kamarudin
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Pharmaceuticals
Subjects:
glioblastoma
ABC transporters
drug transport
increased drug efficacy
temozolomide
alkylating agents
Online Access:https://www.mdpi.com/1424-8247/18/1/102
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