Optimising and adapting perfusion feeds in serum-free medium to intensify CAR-T cell expansion in stirred-tank bioreactors

Optimising and adapting perfusion feeds in serum-free medium to intensify CAR-T cell expansion in stirred-tank bioreactors

The ex vivo expansion of autologous chimeric antigen receptor (CAR) T cells to reach a therapeutic dose significantly prolongs manufacturing time and increases overall costs. The common use of animal- or human-derived serum in T cell expansion culture media further contributes to process variability...

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Bibliographic Details
Main Authors: Pierre Springuel, Tiffany Hood, Fern Slingsby, Timo Schmidberger, Nicola Bevan, Noushin Dianat, Julia Hengst, Qasim A. Rafiq
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
CAR-T cell
perfusion
xeno-and serum-free medium
adaptive
process intensification
stirred-tank bioreactor
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1593895/full
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