The regulatory architecture of the primed pluripotent cell state

Abstract Despite extensive research, the gene regulatory architecture governing mammalian cell states remains poorly understood. Here we present an integrative systems biology approach to elucidate the network architecture of primed state pluripotency. Using an unbiased methodology, we identified an...

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Bibliographic Details
Main Authors: Bo I. Li, Mariano J. Alvarez, Hui Zhao, Napon Chirathivat, Andrea Califano, Michael M. Shen
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57894-4
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