Association between endogenous lactate accumulation and dysregulated activation of the NLRP3 inflammasome pathway in schizophrenia

Association between endogenous lactate accumulation and dysregulated activation of the NLRP3 inflammasome pathway in schizophrenia

Abstract In this study, we retrospectively analyzed whether serum lactate levels were elevated in patients with schizophrenia (SCZ) and explored cognitive deficits, abnormalities in lactate metabolism, and neuroinflammation in an dizocilpine (MK-801)-induced N-methyl-d-aspartate (NMDA) receptor (NMD...

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Bibliographic Details
Main Authors: Yingying Zhang, Yanjun Wang, Haoran Xing, Yuncheng Bai, Mier Li, Haiqiang Zhao, Luanmei Ding, Weiwei Wang, Tianhao Bao
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Schizophrenia
Lactate
MK-801
NLRP3
Caspase-1
Online Access:https://doi.org/10.1038/s41598-025-04823-6
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https://doi.org/10.1038/s41598-025-04823-6

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