Development, Safety, and Therapeutic Evaluation of Voriconazole-Loaded Zein–Pectin–Hyaluronic Acid Nanoparticles Using Alternative In Vivo Models for Efficacy and Toxicity

Development, Safety, and Therapeutic Evaluation of Voriconazole-Loaded Zein–Pectin–Hyaluronic Acid Nanoparticles Using Alternative In Vivo Models for Efficacy and Toxicity

<b>Background/Objectives</b>: Fungal infections caused by <i>Candida</i> species remain a significant clinical challenge, exacerbated by limitations in current antifungal therapies, including toxicity and poor bioavailability. This study aimed to develop and evaluate voricona...

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Main Authors: Margani Taise Fin, Kelvin Sousa dos Santos, Marcos William de Lima Gualque, Rafaela Cristine dos Santos, Natália Cristina Morici Aoki, Marcos Ereno Auler, Ana Marisa Fusco-Almeida, Maria José Soares Mendes-Gianinni, Rubiana Mara Mainardes
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Pharmaceutics
Subjects:
voriconazole
nanoparticles
<i>Candida</i> infections
<i>Caenorhabditis elegans</i>
<i>Galleria mellonella</i>
antifungal therapy
Online Access:https://www.mdpi.com/1999-4923/17/2/231
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