Determination of NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) in plant foods: exploring dietary sources
NAD+ is vital for all living organisms, playing key roles in redox reactions and cellular signaling. Understanding the levels of its biosynthetic precursors, NMN and NR, in foods is essential for assessing their dietary contributions to human nutrition and health. We conducted a comprehensive analys...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | CyTA - Journal of Food |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19476337.2025.2458753 |
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| author | Gabriela Fabiana Soares Alegre Glaucia Maria Pastore |
| author_facet | Gabriela Fabiana Soares Alegre Glaucia Maria Pastore |
| author_sort | Gabriela Fabiana Soares Alegre |
| collection | DOAJ |
| description | NAD+ is vital for all living organisms, playing key roles in redox reactions and cellular signaling. Understanding the levels of its biosynthetic precursors, NMN and NR, in foods is essential for assessing their dietary contributions to human nutrition and health. We conducted a comprehensive analysis of NMN, NR, and NAD+ levels for the first time in various common plant foods and non-conventional food plants from the Amazon, using a validated HPLC-DAD/UV method, further confirmed by LC-MS/MS. NMN concentrations ranged from 40 to 13,000 µg per 100 g of fresh weight, while the NR levels varied from 62 to 1,600 µg per 100 g. Broccoli and green beans were identified as rich sources of NMN, whereas wild chicory, banana, and orange had the highest NR content. This study enhances our understanding of how to optimize NAD+ levels through dietary sources and advances knowledge in food science and nutrition. |
| format | Article |
| id | doaj-art-a29e774428164e78a0dff7c0018b8753 |
| institution | Kabale University |
| issn | 1947-6337 1947-6345 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | CyTA - Journal of Food |
| spelling | doaj-art-a29e774428164e78a0dff7c0018b87532025-02-04T17:03:28ZengTaylor & Francis GroupCyTA - Journal of Food1947-63371947-63452025-12-0123110.1080/19476337.2025.2458753Determination of NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) in plant foods: exploring dietary sourcesGabriela Fabiana Soares Alegre0Glaucia Maria Pastore1Laboratory of Bioflavours and Bioactive Compounds - Department of Food Science and Nutrition, Faculty of Food Engineering, Universidade Estadual de Campinas, Campinas, SP, BrazilLaboratory of Bioflavours and Bioactive Compounds - Department of Food Science and Nutrition, Faculty of Food Engineering, Universidade Estadual de Campinas, Campinas, SP, BrazilNAD+ is vital for all living organisms, playing key roles in redox reactions and cellular signaling. Understanding the levels of its biosynthetic precursors, NMN and NR, in foods is essential for assessing their dietary contributions to human nutrition and health. We conducted a comprehensive analysis of NMN, NR, and NAD+ levels for the first time in various common plant foods and non-conventional food plants from the Amazon, using a validated HPLC-DAD/UV method, further confirmed by LC-MS/MS. NMN concentrations ranged from 40 to 13,000 µg per 100 g of fresh weight, while the NR levels varied from 62 to 1,600 µg per 100 g. Broccoli and green beans were identified as rich sources of NMN, whereas wild chicory, banana, and orange had the highest NR content. This study enhances our understanding of how to optimize NAD+ levels through dietary sources and advances knowledge in food science and nutrition.https://www.tandfonline.com/doi/10.1080/19476337.2025.2458753NAD+ precursorsNMNNRplant foodsHPLC analysis |
| spellingShingle | Gabriela Fabiana Soares Alegre Glaucia Maria Pastore Determination of NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) in plant foods: exploring dietary sources CyTA - Journal of Food NAD+ precursors NMN NR plant foods HPLC analysis |
| title | Determination of NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) in plant foods: exploring dietary sources |
| title_full | Determination of NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) in plant foods: exploring dietary sources |
| title_fullStr | Determination of NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) in plant foods: exploring dietary sources |
| title_full_unstemmed | Determination of NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) in plant foods: exploring dietary sources |
| title_short | Determination of NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) in plant foods: exploring dietary sources |
| title_sort | determination of nad precursors nicotinamide mononucleotide nmn and nicotinamide riboside nr in plant foods exploring dietary sources |
| topic | NAD+ precursors NMN NR plant foods HPLC analysis |
| url | https://www.tandfonline.com/doi/10.1080/19476337.2025.2458753 |
| work_keys_str_mv | AT gabrielafabianasoaresalegre determinationofnadprecursorsnicotinamidemononucleotidenmnandnicotinamideribosidenrinplantfoodsexploringdietarysources AT glauciamariapastore determinationofnadprecursorsnicotinamidemononucleotidenmnandnicotinamideribosidenrinplantfoodsexploringdietarysources |