A QS21 + CpG-Adjuvanted Trivalent HSV-2 Vaccine and Trivalent HSV-2 mRNA Vaccine Induce a Strong Immune Response, Protect Against HSV-2 Infection, and Cross-Protect Against HSV-1 Infection in Mice

A QS21 + CpG-Adjuvanted Trivalent HSV-2 Vaccine and Trivalent HSV-2 mRNA Vaccine Induce a Strong Immune Response, Protect Against HSV-2 Infection, and Cross-Protect Against HSV-1 Infection in Mice

Background: HSV-2 infection continues to be a significant global health concern, as there are no approved vaccines despite numerous attempts at development. Methods: This study explored the immunogenicity and protective efficacy of aluminum- or QS21 + CpG-adjuvanted trivalent HSV-2 vaccines and a tr...

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Main Authors: Han Cao, Xiaolong Zhang, Jishuai Cheng, Yang Li, Ning Luan, Jingping Hu, Bingyan Liang, Haihao Zhang, Dandan Gao, Zhentao Lei, Yufeng Yao, Cunbao Liu
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Vaccines
Subjects:
herpes simplex virus
trivalent antigen
subunit vaccine
mRNA vaccine
cross-protection
Online Access:https://www.mdpi.com/2076-393X/13/5/497
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