The inhibition of TXNRD1 by methylglyoxal impairs the intracellular control of Mycobacterium tuberculosis

The inhibition of TXNRD1 by methylglyoxal impairs the intracellular control of Mycobacterium tuberculosis

Type 2 diabetes (DM) is a risk factor for development of tuberculosis (TB). Methylglyoxal (MGO), a reactive carbonyl increased during DM targets diverse macromolecules. Here we discovered that MGO converted the mammalian selenoprotein thioredoxin reductase 1 (TXNRD1) to a NADPH oxidase, activating t...

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Bibliographic Details
Main Authors: Hanxiong Li, Ruining Liu, Gokul Raj Kathamuthu, Radosveta Gencheva, Zhen Gong, Axel Tobias Scholz, Mohammad Alzrigat, Lucia Coppo, Elias S.J. Arnér, Martin E. Rottenberg
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Redox Biology
Subjects:
Tuberculosis
Diabetes
Macrophage
Methylglyoxal
Thioredoxin reductase
NRF2
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172500254X
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