KRAS amplification in colorectal cancer: correlations with clinicopathological features and prognosis in patients and prediction of response to targeted therapy
Abstract Background Kirsten Rat Sarcoma (KRAS) copy number amplification has emerged as an oncogenic driver in colorectal cancer (CRC), in addition to KRAS mutation. However, its clinical significance remains poorly understood. Notably, CRC patients with wild-type KRAS but harboring KRAS amplificati...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-025-06864-x |
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