Integrative determination of atomic structure of mutant huntingtin exon 1 fibrils implicated in Huntington disease
Abstract Neurodegeneration in Huntington’s disease (HD) is accompanied by the aggregation of fragments of the mutant huntingtin protein, a biomarker of disease progression. A particular pathogenic role has been attributed to the aggregation-prone huntingtin exon 1 (HTTex1), generated by aberrant spl...
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Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2024-12-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-024-55062-8 |
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