Urinary Dickkopf-3 Reflects Disease Severity and Predicts Short-Term Kidney Function Decline in Renal Ciliopathies

Urinary Dickkopf-3 Reflects Disease Severity and Predicts Short-Term Kidney Function Decline in Renal Ciliopathies

Introduction: Phenotypic heterogeneity and unpredictability of individual disease progression present enormous challenges in ultrarare renal ciliopathies. The tubular-derived glycoprotein, Dickkopf-related protein 3 (DKK3) is a promising biomarker for kidney fibrosis and prediction of kidney functio...

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Main Authors: Mareike Dahmer-Heath, Joachim Gerß, Danilo Fliser, Max Christoph Liebau, Thimoteus Speer, Anna-Katharina Telgmann, Kathrin Burgmaier, Petra Pennekamp, Lars Pape, Franz Schaefer, Martin Konrad, Jens Christian König
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Kidney International Reports
Subjects:
DKK3
kidney fibrosis
kidney function decline
pediatric kidney disease
predictive biomarker
renal ciliopathies
Online Access:http://www.sciencedirect.com/science/article/pii/S2468024924019521
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