Molecular correlates of glycine receptor activity in human β cells

Molecular correlates of glycine receptor activity in human β cells

Objectives: Glycine acts in an autocrine positive feedback loop in human β cells through its ionotropic receptors (GlyRs). In type 2 diabetes (T2D), islet GlyR activity is impaired by unknown mechanisms. We sought to investigate if the GlyR dysfunction in T2D is replicated by hyperglycemia per se, a...

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Bibliographic Details
Main Authors: Amanda Schukarucha Gomes, Cara E. Ellis, Aliya F. Spigelman, Theodore dos Santos, Jasmine Maghera, Kunimasa Suzuki, Patrick E. MacDonald
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Metabolism
Subjects:
β cells
Human islets
Glycine receptors
Hyperglycemia
Type 2 diabetes
EIF4EBP1
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825000638
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