Triglyceride metabolism controls inflammation and microglial phenotypes associated with APOE4

Triglyceride metabolism controls inflammation and microglial phenotypes associated with APOE4

Summary: Changes to cellular lipids accompany shifts in microglial cell state, but the functional significance of these metabolic changes remains poorly understood. In human induced pluripotent stem cell-derived microglia, we observed that both extrinsic activation (by lipopolysaccharide treatment)...

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Main Authors: Roxan A. Stephenson, Jordy Sepulveda, Kory R. Johnson, Adrian Lita, Jaanam Gopalakrishnan, Dominic J. Acri, Alexandra Beilina, Linling Cheng, Linda G. Yang, Jessica T. Root, Michael E. Ward, Christian Combs, William C. Skarnes, Mark R. Cookson, Han-Yu Shih, Mioara Larion, G. William Rebeck, Priyanka S. Narayan
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Cell Reports
Subjects:
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725007326
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