NAT10 promotes osteoclastogenesis in inflammatory bone loss by catalyzing Fos mRNA ac4C modification and upregulating MAPK signaling pathway

NAT10 promotes osteoclastogenesis in inflammatory bone loss by catalyzing Fos mRNA ac4C modification and upregulating MAPK signaling pathway

Introduction: Excessive osteoclastogenesis is a key driver of inflammatory bone loss. Suppressing osteoclastogenesis has always been considered essential for the treatment of inflammatory bone loss. N-acetyltransferase 10 (NAT10) is the sole enzyme responsible for N4-acetylcytidine (ac4C) modificati...

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Bibliographic Details
Main Authors: Ruhan Yang, Weijun Yu, Lu Lin, Zhurong Cui, Jiaqi Tang, Guanglong Li, Min Jin, Yuting Gu, Eryi Lu
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Journal of Advanced Research
Subjects:
Inflammatory bone loss
Osteoclastogenesis
NAT10
ac4C modification
c-Fos
MAPK signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123224003187
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