3D-Metal Complexes Derived from Proton Pump Inhibitors-Synthesis, Characterization and Biological Studies
Complexes of lansoprazole 2[[[[3-methyl, 4-(2′,2′,2′-trifluoro-ethoxy)]-2-pyridinyl] methyl]sulfonyl]–1H–benzimidazole (LAN) with chlorides of Co(II), Ni(II), Cu(II), Mn(II) and Zn(II) were synthesized. LAN is a weak base and it can form several complexes with transition and non-transition metal ion...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2012/969760 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566976429424640 |
|---|---|
| author | Suman Malik Supriya Das Archana Singh Liviu Mitu |
| author_facet | Suman Malik Supriya Das Archana Singh Liviu Mitu |
| author_sort | Suman Malik |
| collection | DOAJ |
| description | Complexes of lansoprazole 2[[[[3-methyl, 4-(2′,2′,2′-trifluoro-ethoxy)]-2-pyridinyl] methyl]sulfonyl]–1H–benzimidazole (LAN) with chlorides of Co(II), Ni(II), Cu(II), Mn(II) and Zn(II) were synthesized. LAN is a weak base and it can form several complexes with transition and non-transition metal ions. It should be noticed that the reaction of all the metal salts yielded bis(ligand) complexes of the general formula [ML2(H2O)2] and [ML2] (M = Co, Ni, Cu, Mn and Zn). The complexes were characterized by elemental analysis, molar conductivity, magnetic susceptibility measurements, IR, 1H-NMR, UV-visible spectral studies, ESR, SEM, x-ray diffraction, TGA and mass spectra. In all the complexes ligand is coordinated by participation of the pyridine nitrogen of the benzimidazole ring and sulphonyl group. Electronic spectra and magnetic susceptibility reveal octahedral geometry for Mn(II), Co(II), Ni(II) and Cu(II) complexes and tetrahedral for Zn(II) complex. The antimicrobial activity of the ligand and its complexes against bacteria Pseudomonas aeruginosa, Staphylococcus aureus and fungi Aspergillus niger and Aspergillus flavous were investigated. The effect of metals on the antimicrobial activity of the ligand has been discussed. |
| format | Article |
| id | doaj-art-a1a7519b3f8942a7b3b4b25a3566403b |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-a1a7519b3f8942a7b3b4b25a3566403b2025-02-03T01:02:38ZengWileyE-Journal of Chemistry0973-49452090-98102012-01-01941919192810.1155/2012/9697603D-Metal Complexes Derived from Proton Pump Inhibitors-Synthesis, Characterization and Biological StudiesSuman Malik0Supriya Das1Archana Singh2Liviu Mitu3Sadhu Vaswani College Bairagarh, Department of Chemistry, Bhopal 462030, IndiaSadhu Vaswani College Bairagarh, Department of Chemistry, Bhopal 462030, IndiaSadhu Vaswani College Bairagarh, Department of Chemistry, Bhopal 462030, IndiaUniversity of Pitesti, Department of Physics and Chemistry, Pitesti 110040, RomaniaComplexes of lansoprazole 2[[[[3-methyl, 4-(2′,2′,2′-trifluoro-ethoxy)]-2-pyridinyl] methyl]sulfonyl]–1H–benzimidazole (LAN) with chlorides of Co(II), Ni(II), Cu(II), Mn(II) and Zn(II) were synthesized. LAN is a weak base and it can form several complexes with transition and non-transition metal ions. It should be noticed that the reaction of all the metal salts yielded bis(ligand) complexes of the general formula [ML2(H2O)2] and [ML2] (M = Co, Ni, Cu, Mn and Zn). The complexes were characterized by elemental analysis, molar conductivity, magnetic susceptibility measurements, IR, 1H-NMR, UV-visible spectral studies, ESR, SEM, x-ray diffraction, TGA and mass spectra. In all the complexes ligand is coordinated by participation of the pyridine nitrogen of the benzimidazole ring and sulphonyl group. Electronic spectra and magnetic susceptibility reveal octahedral geometry for Mn(II), Co(II), Ni(II) and Cu(II) complexes and tetrahedral for Zn(II) complex. The antimicrobial activity of the ligand and its complexes against bacteria Pseudomonas aeruginosa, Staphylococcus aureus and fungi Aspergillus niger and Aspergillus flavous were investigated. The effect of metals on the antimicrobial activity of the ligand has been discussed.http://dx.doi.org/10.1155/2012/969760 |
| spellingShingle | Suman Malik Supriya Das Archana Singh Liviu Mitu 3D-Metal Complexes Derived from Proton Pump Inhibitors-Synthesis, Characterization and Biological Studies E-Journal of Chemistry |
| title | 3D-Metal Complexes Derived from Proton Pump Inhibitors-Synthesis, Characterization and Biological Studies |
| title_full | 3D-Metal Complexes Derived from Proton Pump Inhibitors-Synthesis, Characterization and Biological Studies |
| title_fullStr | 3D-Metal Complexes Derived from Proton Pump Inhibitors-Synthesis, Characterization and Biological Studies |
| title_full_unstemmed | 3D-Metal Complexes Derived from Proton Pump Inhibitors-Synthesis, Characterization and Biological Studies |
| title_short | 3D-Metal Complexes Derived from Proton Pump Inhibitors-Synthesis, Characterization and Biological Studies |
| title_sort | 3d metal complexes derived from proton pump inhibitors synthesis characterization and biological studies |
| url | http://dx.doi.org/10.1155/2012/969760 |
| work_keys_str_mv | AT sumanmalik 3dmetalcomplexesderivedfromprotonpumpinhibitorssynthesischaracterizationandbiologicalstudies AT supriyadas 3dmetalcomplexesderivedfromprotonpumpinhibitorssynthesischaracterizationandbiologicalstudies AT archanasingh 3dmetalcomplexesderivedfromprotonpumpinhibitorssynthesischaracterizationandbiologicalstudies AT liviumitu 3dmetalcomplexesderivedfromprotonpumpinhibitorssynthesischaracterizationandbiologicalstudies |