PD‐L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy

PD‐L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy

Abstract Pancreatic ductal adenocarcinoma (PDAC) is considered a non‐immunogenic tumor, and immune checkpoint inhibitor monotherapy lacks efficacy in this disease. Radiotherapy (RT) can stimulate the immune system. Here, we show that treatment of KPC and Pan02 murine PDAC cells with RT and gemcitabi...

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Main Authors: Abul Azad, Su Yin Lim, Zenobia D'Costa, Keaton Jones, Angela Diana, Owen J Sansom, Philipp Kruger, Stanley Liu, W Gillies McKenna, Omer Dushek, Ruth J Muschel, Emmanouil Fokas
Format: Article
Language:English
Published: Springer Nature 2016-12-01
Series:EMBO Molecular Medicine
Subjects:
liver metastases
mathematical modeling
pancreatic cancer
PD‐L1 immune checkpoint
radiosensitization
Online Access:https://doi.org/10.15252/emmm.201606674
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https://doi.org/10.15252/emmm.201606674

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