Progress in personalized immunotherapy for patients with brain metastasis
Abstract Brain metastasis leads to poor outcomes and CNS injury, significantly reducing quality of life and survival rates. Advances in understanding the tumor immune microenvironment have revealed the promise of immunotherapies, which, alongside surgery, chemotherapy, and radiation, offer improved...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Precision Oncology |
| Online Access: | https://doi.org/10.1038/s41698-025-00812-0 |
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| _version_ | 1832572087274831872 |
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| author | Lalit Patel Nikola Kolundzic Malak Abedalthagafi |
| author_facet | Lalit Patel Nikola Kolundzic Malak Abedalthagafi |
| author_sort | Lalit Patel |
| collection | DOAJ |
| description | Abstract Brain metastasis leads to poor outcomes and CNS injury, significantly reducing quality of life and survival rates. Advances in understanding the tumor immune microenvironment have revealed the promise of immunotherapies, which, alongside surgery, chemotherapy, and radiation, offer improved survival for some patients. However, resistance to immunotherapy remains a critical challenge. This review explores the immune landscape of brain metastases, current therapies, clinical trials, and the need for personalized, biomarker-driven approaches to optimize outcomes. |
| format | Article |
| id | doaj-art-a16b095e45d545bdae91c717641ba0fe |
| institution | Kabale University |
| issn | 2397-768X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Precision Oncology |
| spelling | doaj-art-a16b095e45d545bdae91c717641ba0fe2025-02-02T12:06:34ZengNature Portfolionpj Precision Oncology2397-768X2025-01-019111310.1038/s41698-025-00812-0Progress in personalized immunotherapy for patients with brain metastasisLalit Patel0Nikola Kolundzic1Malak Abedalthagafi2Department of Pathology and Lab Medicine, Emory University School of MedicineDepartment of Women & Children’s Health, Faculty of Life Sciences & Medicine, King’s College LondonDepartment of Pathology and Lab Medicine, Emory University School of MedicineAbstract Brain metastasis leads to poor outcomes and CNS injury, significantly reducing quality of life and survival rates. Advances in understanding the tumor immune microenvironment have revealed the promise of immunotherapies, which, alongside surgery, chemotherapy, and radiation, offer improved survival for some patients. However, resistance to immunotherapy remains a critical challenge. This review explores the immune landscape of brain metastases, current therapies, clinical trials, and the need for personalized, biomarker-driven approaches to optimize outcomes.https://doi.org/10.1038/s41698-025-00812-0 |
| spellingShingle | Lalit Patel Nikola Kolundzic Malak Abedalthagafi Progress in personalized immunotherapy for patients with brain metastasis npj Precision Oncology |
| title | Progress in personalized immunotherapy for patients with brain metastasis |
| title_full | Progress in personalized immunotherapy for patients with brain metastasis |
| title_fullStr | Progress in personalized immunotherapy for patients with brain metastasis |
| title_full_unstemmed | Progress in personalized immunotherapy for patients with brain metastasis |
| title_short | Progress in personalized immunotherapy for patients with brain metastasis |
| title_sort | progress in personalized immunotherapy for patients with brain metastasis |
| url | https://doi.org/10.1038/s41698-025-00812-0 |
| work_keys_str_mv | AT lalitpatel progressinpersonalizedimmunotherapyforpatientswithbrainmetastasis AT nikolakolundzic progressinpersonalizedimmunotherapyforpatientswithbrainmetastasis AT malakabedalthagafi progressinpersonalizedimmunotherapyforpatientswithbrainmetastasis |