Chaperone-Mediated Responses and Mitochondrial–Endoplasmic Reticulum Coupling: Emerging Insight into Alzheimer’s Disease

Chaperone-Mediated Responses and Mitochondrial–Endoplasmic Reticulum Coupling: Emerging Insight into Alzheimer’s Disease

Alzheimer’s disease (AD) is increasingly recognized as a multifactorial disorder driven by a combination of disruptions in proteostasis and organelle communication. The 2020 Lancet commission reported that approximately 10 million people worldwide were affected by AD in the mid-20th century. AD is t...

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Bibliographic Details
Main Authors: Manish Kumar Singh, Minghao Fu, Sunhee Han, Jyotsna S. Ranbhise, Wonchae Choe, Sung Soo Kim, Insug Kang
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Cells
Subjects:
Alzheimer’s disease
amyloid-β
aggregates
calcium
chaperones
endoplasmic reticulum
Online Access:https://www.mdpi.com/2073-4409/14/15/1179
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