Efficacy of alpelisib with rational use of metformin in HR+/HER2- advanced breast cancer patients with <i>PIK3CA</i> mutations (m): retrospective analysis in routine practice of several Russian centers

Efficacy of alpelisib with rational use of metformin in HR+/HER2- advanced breast cancer patients with <i>PIK3CA</i> mutations (m): retrospective analysis in routine practice of several Russian centers

Background. Hyperglycemia (HG) is an on-target effect of ALP, and prophylactic with metformin was shown to decrease the rate and severity of HG. Here we present efficacy and safety of ALP in a large cohort of patients with rational approach to metformin usage based on risk factors of HG. Material an...

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Bibliographic Details
Main Authors: D. A. Filonenko, R. V. Orlova, M. I. Gluzman, A. A. Vakhitova, A. Yu. Goryainova, K. S. Grechukhina, I. I. Bykonya, L. G. Zhukova
Format: Article
Language:Russian
Published: Russian Academy of Sciences, Tomsk National Research Medical Center 2025-01-01
Series:Сибирский онкологический журнал
Subjects:
alpelisib
hyperglycemia
metformin
breast cancer
Online Access:https://www.siboncoj.ru/jour/article/view/3353
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