Association between Clinical Characteristics and Laboratory Findings with Outcome of Hospitalized COVID-19 Patients: A Report from Northeast Iran
Coronavirus disease 2019 (COVID-19) was first discovered in December 2019 in China and has rapidly spread worldwide. Clinical characteristics, laboratory findings, and their association with the outcome of patients with COVID-19 can be decisive in management and early diagnosis. Data were obtained r...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2021/5552138 |
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| author | Sahar Sobhani Reihaneh Aryan Elham Kalantari Salman Soltani Nafise Malek Parisa Pirzadeh Amir Yarahmadi Atena Aghaee |
| author_facet | Sahar Sobhani Reihaneh Aryan Elham Kalantari Salman Soltani Nafise Malek Parisa Pirzadeh Amir Yarahmadi Atena Aghaee |
| author_sort | Sahar Sobhani |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19) was first discovered in December 2019 in China and has rapidly spread worldwide. Clinical characteristics, laboratory findings, and their association with the outcome of patients with COVID-19 can be decisive in management and early diagnosis. Data were obtained retrospectively from medical records of 397 hospitalized COVID-19 patients between February and May 2020 in Imam Reza Hospital, northeast Iran. Clinical and laboratory features were evaluated among survivors and nonsurvivors. The correlation between variables and duration of hospitalization and admission to the intensive care unit (ICU) was determined. Male sex, age, hospitalization duration, and admission to ICU were significantly related to mortality rate. Headache was a more common feature in patients who survived (p=0.017). It was also related to a shorter stay in the hospital (p=0.032) as opposed to patients who experienced chest pain (p=0.033). Decreased levels of consciousness and dyspnea were statistically more frequent in nonsurvivors (p=0.003 and p=0.011, respectively). Baseline white blood cell (WBC) count, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were significantly higher in nonsurvivors (p<0.001). Patients with higher WBC and CRP levels were more likely to be admitted to ICU (p=0.009 and p=0.001, respectively). Evaluating clinical and laboratory features can help clinicians find ways for risk stratifying patients and even make predictive tools. Chest pain, decreased level of consciousness, dyspnea, and increased CRP and WBC levels seem to be the most potent predictors of severe prognosis. |
| format | Article |
| id | doaj-art-a12caf65200f4039b9fef2ce1efd2062 |
| institution | Kabale University |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-a12caf65200f4039b9fef2ce1efd20622025-02-03T01:20:32ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982021-01-01202110.1155/2021/55521385552138Association between Clinical Characteristics and Laboratory Findings with Outcome of Hospitalized COVID-19 Patients: A Report from Northeast IranSahar Sobhani0Reihaneh Aryan1Elham Kalantari2Salman Soltani3Nafise Malek4Parisa Pirzadeh5Amir Yarahmadi6Atena Aghaee7Department of Nursing and Midwifery, Faculty of Nursing, Gonabad University of Medical Sciences, Gonabad, IranClinical Research Development Unit, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IranAssistant Professor of Pulmonology, Department of Pulmonology, Isfahan University of Medical Science, Isfahan, IranKidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, IranDepartment of Nursing and Midwifery, Faculty of Nursing, Mashhad University of Medical Sciences, Mashhad, IranTransplant Research Center, Shiraz University of Medical Sciences, Shiraz, IranNuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, IranCoronavirus disease 2019 (COVID-19) was first discovered in December 2019 in China and has rapidly spread worldwide. Clinical characteristics, laboratory findings, and their association with the outcome of patients with COVID-19 can be decisive in management and early diagnosis. Data were obtained retrospectively from medical records of 397 hospitalized COVID-19 patients between February and May 2020 in Imam Reza Hospital, northeast Iran. Clinical and laboratory features were evaluated among survivors and nonsurvivors. The correlation between variables and duration of hospitalization and admission to the intensive care unit (ICU) was determined. Male sex, age, hospitalization duration, and admission to ICU were significantly related to mortality rate. Headache was a more common feature in patients who survived (p=0.017). It was also related to a shorter stay in the hospital (p=0.032) as opposed to patients who experienced chest pain (p=0.033). Decreased levels of consciousness and dyspnea were statistically more frequent in nonsurvivors (p=0.003 and p=0.011, respectively). Baseline white blood cell (WBC) count, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were significantly higher in nonsurvivors (p<0.001). Patients with higher WBC and CRP levels were more likely to be admitted to ICU (p=0.009 and p=0.001, respectively). Evaluating clinical and laboratory features can help clinicians find ways for risk stratifying patients and even make predictive tools. Chest pain, decreased level of consciousness, dyspnea, and increased CRP and WBC levels seem to be the most potent predictors of severe prognosis.http://dx.doi.org/10.1155/2021/5552138 |
| spellingShingle | Sahar Sobhani Reihaneh Aryan Elham Kalantari Salman Soltani Nafise Malek Parisa Pirzadeh Amir Yarahmadi Atena Aghaee Association between Clinical Characteristics and Laboratory Findings with Outcome of Hospitalized COVID-19 Patients: A Report from Northeast Iran Interdisciplinary Perspectives on Infectious Diseases |
| title | Association between Clinical Characteristics and Laboratory Findings with Outcome of Hospitalized COVID-19 Patients: A Report from Northeast Iran |
| title_full | Association between Clinical Characteristics and Laboratory Findings with Outcome of Hospitalized COVID-19 Patients: A Report from Northeast Iran |
| title_fullStr | Association between Clinical Characteristics and Laboratory Findings with Outcome of Hospitalized COVID-19 Patients: A Report from Northeast Iran |
| title_full_unstemmed | Association between Clinical Characteristics and Laboratory Findings with Outcome of Hospitalized COVID-19 Patients: A Report from Northeast Iran |
| title_short | Association between Clinical Characteristics and Laboratory Findings with Outcome of Hospitalized COVID-19 Patients: A Report from Northeast Iran |
| title_sort | association between clinical characteristics and laboratory findings with outcome of hospitalized covid 19 patients a report from northeast iran |
| url | http://dx.doi.org/10.1155/2021/5552138 |
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