Spray-Dried Griseofulvin-Lactose Matrix for Enhanced Solubility Using a Spray-Drying Biochemical Process
Griseofulvin (GF) is a hydrophobic drug with a low solubility. In order to improve the solubility of GF, which has low water solubility, this report uses the spray-drying technique to prepare complexes with lactose to promote the solubility and oral bioavailability of GF. The solution samples were s...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2022/8372048 |
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| _version_ | 1832565522145738752 |
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| author | Tian Lan Jie Yang Zhi-jie Yang Hong-wen Wu |
| author_facet | Tian Lan Jie Yang Zhi-jie Yang Hong-wen Wu |
| author_sort | Tian Lan |
| collection | DOAJ |
| description | Griseofulvin (GF) is a hydrophobic drug with a low solubility. In order to improve the solubility of GF, which has low water solubility, this report uses the spray-drying technique to prepare complexes with lactose to promote the solubility and oral bioavailability of GF. The solution samples were spray dried using different ratios of ethanol or acetone solutions as dissolution media. By characterization of the obtained spray-dried powders, we found that the solubility of the different groups of samples obtained by spray drying was increased, and similarly, their dissolution rates were also increased to different degrees. By comparison, the greatest increase in solubility was obtained in an aqueous acetone solution, showing the greatest ability and efficiency of acetone in promoting the solubility of GF during the spray-drying process. |
| format | Article |
| id | doaj-art-a117064fab914fa292b3263bdb6aba76 |
| institution | Kabale University |
| issn | 2090-9071 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-a117064fab914fa292b3263bdb6aba762025-02-03T01:07:24ZengWileyJournal of Chemistry2090-90712022-01-01202210.1155/2022/8372048Spray-Dried Griseofulvin-Lactose Matrix for Enhanced Solubility Using a Spray-Drying Biochemical ProcessTian Lan0Jie Yang1Zhi-jie Yang2Hong-wen Wu3Department of PharmacyDepartment of Science and EducationDepartment of PharmacyDepartment of PharmacyGriseofulvin (GF) is a hydrophobic drug with a low solubility. In order to improve the solubility of GF, which has low water solubility, this report uses the spray-drying technique to prepare complexes with lactose to promote the solubility and oral bioavailability of GF. The solution samples were spray dried using different ratios of ethanol or acetone solutions as dissolution media. By characterization of the obtained spray-dried powders, we found that the solubility of the different groups of samples obtained by spray drying was increased, and similarly, their dissolution rates were also increased to different degrees. By comparison, the greatest increase in solubility was obtained in an aqueous acetone solution, showing the greatest ability and efficiency of acetone in promoting the solubility of GF during the spray-drying process.http://dx.doi.org/10.1155/2022/8372048 |
| spellingShingle | Tian Lan Jie Yang Zhi-jie Yang Hong-wen Wu Spray-Dried Griseofulvin-Lactose Matrix for Enhanced Solubility Using a Spray-Drying Biochemical Process Journal of Chemistry |
| title | Spray-Dried Griseofulvin-Lactose Matrix for Enhanced Solubility Using a Spray-Drying Biochemical Process |
| title_full | Spray-Dried Griseofulvin-Lactose Matrix for Enhanced Solubility Using a Spray-Drying Biochemical Process |
| title_fullStr | Spray-Dried Griseofulvin-Lactose Matrix for Enhanced Solubility Using a Spray-Drying Biochemical Process |
| title_full_unstemmed | Spray-Dried Griseofulvin-Lactose Matrix for Enhanced Solubility Using a Spray-Drying Biochemical Process |
| title_short | Spray-Dried Griseofulvin-Lactose Matrix for Enhanced Solubility Using a Spray-Drying Biochemical Process |
| title_sort | spray dried griseofulvin lactose matrix for enhanced solubility using a spray drying biochemical process |
| url | http://dx.doi.org/10.1155/2022/8372048 |
| work_keys_str_mv | AT tianlan spraydriedgriseofulvinlactosematrixforenhancedsolubilityusingaspraydryingbiochemicalprocess AT jieyang spraydriedgriseofulvinlactosematrixforenhancedsolubilityusingaspraydryingbiochemicalprocess AT zhijieyang spraydriedgriseofulvinlactosematrixforenhancedsolubilityusingaspraydryingbiochemicalprocess AT hongwenwu spraydriedgriseofulvinlactosematrixforenhancedsolubilityusingaspraydryingbiochemicalprocess |