Unraveling Ferroptosis: A New Frontier in Combating Renal Fibrosis and CKD Progression
Chronic kidney disease (CKD) is a global health concern caused by conditions such as hypertension, diabetes, hyperlipidemia, and chronic nephritis, leading to structural and functional kidney injury. Kidney fibrosis is a common outcome of CKD progression, with abnormal fatty acid oxidation (FAO) dis...
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MDPI AG
2024-12-01
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| author | Rui Jin Yue Dai Zheng Wang Qinyang Hu Cuntai Zhang Hongyu Gao Qi Yan |
| author_facet | Rui Jin Yue Dai Zheng Wang Qinyang Hu Cuntai Zhang Hongyu Gao Qi Yan |
| author_sort | Rui Jin |
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| description | Chronic kidney disease (CKD) is a global health concern caused by conditions such as hypertension, diabetes, hyperlipidemia, and chronic nephritis, leading to structural and functional kidney injury. Kidney fibrosis is a common outcome of CKD progression, with abnormal fatty acid oxidation (FAO) disrupting renal energy homeostasis and leading to functional impairments. This results in maladaptive repair mechanisms and the secretion of profibrotic factors, and exacerbates renal fibrosis. Understanding the molecular mechanisms of renal fibrosis is crucial for delaying CKD progression. Ferroptosis is a type of discovered an iron-dependent lipid peroxidation-regulated cell death. Notably, Ferroptosis contributes to tissue and organ fibrosis, which is correlated with the degree of renal fibrosis. This study aims to clarify the complex mechanisms of ferroptosis in renal parenchymal cells and explore how ferroptosis intervention may help alleviate renal fibrosis, particularly by addressing the gap in CKD mechanisms related to abnormal lipid metabolism under the ferroptosis context. The goal is to provide a new theoretical basis for clinically delaying CKD progression. |
| format | Article |
| id | doaj-art-a0ec00bf3fd74fa78b25f729cf71ac90 |
| institution | Kabale University |
| issn | 2079-7737 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj-art-a0ec00bf3fd74fa78b25f729cf71ac902025-01-24T13:23:18ZengMDPI AGBiology2079-77372024-12-011411210.3390/biology14010012Unraveling Ferroptosis: A New Frontier in Combating Renal Fibrosis and CKD ProgressionRui Jin0Yue Dai1Zheng Wang2Qinyang Hu3Cuntai Zhang4Hongyu Gao5Qi Yan6Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaChronic kidney disease (CKD) is a global health concern caused by conditions such as hypertension, diabetes, hyperlipidemia, and chronic nephritis, leading to structural and functional kidney injury. Kidney fibrosis is a common outcome of CKD progression, with abnormal fatty acid oxidation (FAO) disrupting renal energy homeostasis and leading to functional impairments. This results in maladaptive repair mechanisms and the secretion of profibrotic factors, and exacerbates renal fibrosis. Understanding the molecular mechanisms of renal fibrosis is crucial for delaying CKD progression. Ferroptosis is a type of discovered an iron-dependent lipid peroxidation-regulated cell death. Notably, Ferroptosis contributes to tissue and organ fibrosis, which is correlated with the degree of renal fibrosis. This study aims to clarify the complex mechanisms of ferroptosis in renal parenchymal cells and explore how ferroptosis intervention may help alleviate renal fibrosis, particularly by addressing the gap in CKD mechanisms related to abnormal lipid metabolism under the ferroptosis context. The goal is to provide a new theoretical basis for clinically delaying CKD progression.https://www.mdpi.com/2079-7737/14/1/12ferroptosiscell deathmolecular mechanismchronic kidney disease (CKD)renal fibrosis |
| spellingShingle | Rui Jin Yue Dai Zheng Wang Qinyang Hu Cuntai Zhang Hongyu Gao Qi Yan Unraveling Ferroptosis: A New Frontier in Combating Renal Fibrosis and CKD Progression Biology ferroptosis cell death molecular mechanism chronic kidney disease (CKD) renal fibrosis |
| title | Unraveling Ferroptosis: A New Frontier in Combating Renal Fibrosis and CKD Progression |
| title_full | Unraveling Ferroptosis: A New Frontier in Combating Renal Fibrosis and CKD Progression |
| title_fullStr | Unraveling Ferroptosis: A New Frontier in Combating Renal Fibrosis and CKD Progression |
| title_full_unstemmed | Unraveling Ferroptosis: A New Frontier in Combating Renal Fibrosis and CKD Progression |
| title_short | Unraveling Ferroptosis: A New Frontier in Combating Renal Fibrosis and CKD Progression |
| title_sort | unraveling ferroptosis a new frontier in combating renal fibrosis and ckd progression |
| topic | ferroptosis cell death molecular mechanism chronic kidney disease (CKD) renal fibrosis |
| url | https://www.mdpi.com/2079-7737/14/1/12 |
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