Changes in Serum Cytokine Levels in Active Tuberculosis With Treatment
It has been reported that IFN-γ, TNF-α, and IL-12 stimulate, and that IL-10, TGF-β, and IL-4 suppress the protective immune response against tuberculosis. We aim to evaluate changes in the serum levels of pro and antiinflammatory cytokines in active pulmonary tuberculosis (APTB) and the possible eff...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2005-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI.2005.256 |
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| Summary: | It has been reported that IFN-γ, TNF-α, and IL-12
stimulate, and that IL-10, TGF-β, and IL-4 suppress the
protective immune response against tuberculosis. We aim
to evaluate changes in the serum levels of pro and
antiinflammatory cytokines in active pulmonary tuberculosis
(APTB) and the possible effects of treatment on these changes.
Serum IL-12p40, IL-4, IL-10, TNF-α, IFN-γ, and
TGF-β1 levels were determined in 20 APTB cases (group 1)
before and 2, 4, and 6 months after therapy. The same parameters
were also determined in 9 inactive pulmonary tuberculosis (IPTB)
cases (group 2) and 9 healthy controls (HC, group 3). Before
treatment, the mean serum IFN-γ, TNF-α, and IL-10
levels in group 1 were statistically higher than those in group 2
(P=.001, P=.024, P=.016, resp) or group 3 (P=.003, P=.002, P=.011, resp). The levels in group 1 decreased
significantly after treatment (P=.001 for IFN-γ,
P=.004
for TNF-α, P=.000 for IL-10). The serum levels
of IL-12p40 were significantly higher in group 1 than in group 3
(P=.012) and decreased insignificantly after treatment. There
was no difference in serum IL-4 and TGF-β1 levels among the
groups (P>.05). Because the serum IL-12p40, IL-10, TNF-α,
and IFN-γ levels were high in APTB, we believe that these
cytokines have important roles in the immune response to
Mycobacterium tuberculosis (M tuberculosis).
These parameters could be used in follow-up as indicators of the
success of APTB therapy. |
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| ISSN: | 0962-9351 1466-1861 |