Potential common targets of music therapy intervention in neuropsychiatric disorders: the prefrontal cortex-hippocampus -amygdala circuit (a review)
As life becomes more stressful, neurological disorders, psychiatric disorders, and comorbidities of the two are becoming more and more of a concern. Multiple neuropsychiatric disorders share the same mental and somatic dysfunction and may involve common brain circuits and mechanistic targets. Music...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2025.1471433/full |
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| author | Yuqin Dan Ying Xiong Danghan Xu Yuqi Wang Meng Yin Pengwei Sun Yi Ding Ziyun Feng Peng Sun Weili Xia Gongchang Yu Gongchang Yu Li Li Li Li |
| author_facet | Yuqin Dan Ying Xiong Danghan Xu Yuqi Wang Meng Yin Pengwei Sun Yi Ding Ziyun Feng Peng Sun Weili Xia Gongchang Yu Gongchang Yu Li Li Li Li |
| author_sort | Yuqin Dan |
| collection | DOAJ |
| description | As life becomes more stressful, neurological disorders, psychiatric disorders, and comorbidities of the two are becoming more and more of a concern. Multiple neuropsychiatric disorders share the same mental and somatic dysfunction and may involve common brain circuits and mechanistic targets. Music therapy, as an art form with proven efficacy, low cost and few side effects, is promoted for use in interventions for neuropsychiatric disorders. This may be closely related to the release of signaling molecules such as monoamine neurotransmitters, the glutamatergic system, the gut-microbiota-brain axis, pro-inflammatory cytokines and the endogenous opioid peptide system. However, fewer studies have mentioned the main targets of music to promote functional changes in brain regions. Therefore, this paper is a review of the mechanisms by which music therapy interacts with the prefrontal cortex-hippocampus-amygdala circuit through the aforementioned molecules. It is also hypothesized that glial cells, mitochondria and microRNAs are microscopic targets for musical intervention in neuropsychiatric disorders. The aim is to give new ideas for future research into the biological mechanisms of music therapy intervention in neuropsychiatric disorders. |
| format | Article |
| id | doaj-art-a0dc59ea29cf4639932e79516f935cc3 |
| institution | Kabale University |
| issn | 1662-5161 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj-art-a0dc59ea29cf4639932e79516f935cc32025-02-03T16:46:23ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612025-02-011910.3389/fnhum.2025.14714331471433Potential common targets of music therapy intervention in neuropsychiatric disorders: the prefrontal cortex-hippocampus -amygdala circuit (a review)Yuqin Dan0Ying Xiong1Danghan Xu2Yuqi Wang3Meng Yin4Pengwei Sun5Yi Ding6Ziyun Feng7Peng Sun8Weili Xia9Gongchang Yu10Gongchang Yu11Li Li12Li Li13The College of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaSchool of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaRehabilitation Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe College of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaShandong First Medical University & Shandong Academy of Medical Sciences, Shandong Academy of Occupational Health and Occupational Medicine, Jinan, ChinaSchool of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, ChinaDepartment Rehabilitation Medicine, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ChinaDepartment Rehabilitation Medicine, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ChinaInnovation Research Institute of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaShandong Mental Health Center, Shandong University, Jinan, ChinaShandong Mental Health Center, Shandong University, Jinan, ChinaNeck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaThe College of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaDepartment Rehabilitation Medicine, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ChinaAs life becomes more stressful, neurological disorders, psychiatric disorders, and comorbidities of the two are becoming more and more of a concern. Multiple neuropsychiatric disorders share the same mental and somatic dysfunction and may involve common brain circuits and mechanistic targets. Music therapy, as an art form with proven efficacy, low cost and few side effects, is promoted for use in interventions for neuropsychiatric disorders. This may be closely related to the release of signaling molecules such as monoamine neurotransmitters, the glutamatergic system, the gut-microbiota-brain axis, pro-inflammatory cytokines and the endogenous opioid peptide system. However, fewer studies have mentioned the main targets of music to promote functional changes in brain regions. Therefore, this paper is a review of the mechanisms by which music therapy interacts with the prefrontal cortex-hippocampus-amygdala circuit through the aforementioned molecules. It is also hypothesized that glial cells, mitochondria and microRNAs are microscopic targets for musical intervention in neuropsychiatric disorders. The aim is to give new ideas for future research into the biological mechanisms of music therapy intervention in neuropsychiatric disorders.https://www.frontiersin.org/articles/10.3389/fnhum.2025.1471433/fullneuropsychiatric disordersmusic therapythe prefrontal cortex-hippocampus -amygdala circuitpotential mechanismscommon targets |
| spellingShingle | Yuqin Dan Ying Xiong Danghan Xu Yuqi Wang Meng Yin Pengwei Sun Yi Ding Ziyun Feng Peng Sun Weili Xia Gongchang Yu Gongchang Yu Li Li Li Li Potential common targets of music therapy intervention in neuropsychiatric disorders: the prefrontal cortex-hippocampus -amygdala circuit (a review) Frontiers in Human Neuroscience neuropsychiatric disorders music therapy the prefrontal cortex-hippocampus -amygdala circuit potential mechanisms common targets |
| title | Potential common targets of music therapy intervention in neuropsychiatric disorders: the prefrontal cortex-hippocampus -amygdala circuit (a review) |
| title_full | Potential common targets of music therapy intervention in neuropsychiatric disorders: the prefrontal cortex-hippocampus -amygdala circuit (a review) |
| title_fullStr | Potential common targets of music therapy intervention in neuropsychiatric disorders: the prefrontal cortex-hippocampus -amygdala circuit (a review) |
| title_full_unstemmed | Potential common targets of music therapy intervention in neuropsychiatric disorders: the prefrontal cortex-hippocampus -amygdala circuit (a review) |
| title_short | Potential common targets of music therapy intervention in neuropsychiatric disorders: the prefrontal cortex-hippocampus -amygdala circuit (a review) |
| title_sort | potential common targets of music therapy intervention in neuropsychiatric disorders the prefrontal cortex hippocampus amygdala circuit a review |
| topic | neuropsychiatric disorders music therapy the prefrontal cortex-hippocampus -amygdala circuit potential mechanisms common targets |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2025.1471433/full |
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