Prevalence, clinical characteristics, and biological markers of postmenopausal osteoporosis and knee osteoarthritis in Beijing: study protocol for a cross-sectional and prospective study

Prevalence, clinical characteristics, and biological markers of postmenopausal osteoporosis and knee osteoarthritis in Beijing: study protocol for a cross-sectional and prospective study

BackgroundPostmenopausal osteoporosis (PMOP) and knee osteoarthritis (KOA) are common musculoskeletal disorders that share risk factors such as aging, hormonal changes, and inflammation. PMOP often remains asymptomatic until fractures occur, while KOA leads to pain and disability. Their comorbidity...

Full description

Saved in:
Bibliographic Details
Main Authors: Zhenkai Lu, Wenye Feng, Yaxing Wang, Xuming Zhang, Xu Wei, Ming Chen, Shangquan Wang, Ting Cheng, Xin Cui, Yanming Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Medicine
Subjects:
postmenopausal osteoporosis
knee osteoarthritis
cross-sectional study
prospective
follow-up
risk factors
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2025.1582533/full
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BackgroundPostmenopausal osteoporosis (PMOP) and knee osteoarthritis (KOA) are common musculoskeletal disorders that share risk factors such as aging, hormonal changes, and inflammation. PMOP often remains asymptomatic until fractures occur, while KOA leads to pain and disability. Their comorbidity remains underexplored, particularly in community settings. This study aims to investigate the prevalence, risk factors, and clinical features of PMOP-KOA comorbidity among Beijing residents aged 45–80 years, providing evidence-based recommendations for early identification, prevention, and management.MethodsOver 2 years, this study will conduct a PMOP-KOA screening and prospective follow-up in the Beijing community to investigate the incidence, risk factors, and clinical characteristics of PMOP-KOA. This study will undertake bone mineral density detection, collect biological samples, and record information via questionnaires.DiscussionThe study aims to investigate the incidence, risk factors, and clinical characteristics of PMOP-KOA comorbidity and explore related traditional Chinese medicine syndromes based on large community-based samples in Beijing. Data on PMOP-KOA occurrence and associated risk factors over the 2 years follow-up will be available on the Chinese Clinical Trial Registry (ChiCTR2300073575).
ISSN:2296-858X

Similar Items