MAML2-Rearranged Mucoepidermoid Carcinoma of the Parotid Gland: A Report in a 20-Month-Old Toddler
Malignancies of salivary gland origin are rare in children. Mucoepidermoid carcinoma (MEC) is the most common histologic type of salivary gland neoplasm in pediatrics. We report a rare case of parotid MEC in a 20-month-old female patient. The tumor was composed of nests of epidermoid cells with nucl...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2022/8749836 |
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| author | Adepitan A. Owosho Abiodun S. Olatunji Adewale F. Adejobi Olawumi A. Fatusi Toluwaniyin Okunade Kelly Maddux Justin Shaw Kurt F. Summersgill |
| author_facet | Adepitan A. Owosho Abiodun S. Olatunji Adewale F. Adejobi Olawumi A. Fatusi Toluwaniyin Okunade Kelly Maddux Justin Shaw Kurt F. Summersgill |
| author_sort | Adepitan A. Owosho |
| collection | DOAJ |
| description | Malignancies of salivary gland origin are rare in children. Mucoepidermoid carcinoma (MEC) is the most common histologic type of salivary gland neoplasm in pediatrics. We report a rare case of parotid MEC in a 20-month-old female patient. The tumor was composed of nests of epidermoid cells with nuclei appearing vesicular, pleomorphic, and hyperchromatic with an admixture of mucous cells and cystic spaces within a prominent connective tissue stroma. Immunohistochemically, the epidermoid cells showed cytokeratin 7 and P63 positivity, and mucous cells were positive for mucicarmine. Molecularly, this case was positive for MAML2 rearrangement by FISH. To our knowledge, this is one of the youngest cases of MEC of the parotid gland reported in the English literature. |
| format | Article |
| id | doaj-art-a0a4bec0a6114727bd4a4512f9cf7def |
| institution | Kabale University |
| issn | 2090-6455 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dentistry |
| spelling | doaj-art-a0a4bec0a6114727bd4a4512f9cf7def2025-02-03T06:14:14ZengWileyCase Reports in Dentistry2090-64552022-01-01202210.1155/2022/8749836MAML2-Rearranged Mucoepidermoid Carcinoma of the Parotid Gland: A Report in a 20-Month-Old ToddlerAdepitan A. Owosho0Abiodun S. Olatunji1Adewale F. Adejobi2Olawumi A. Fatusi3Toluwaniyin Okunade4Kelly Maddux5Justin Shaw6Kurt F. Summersgill7Missouri School of Dentistry and Oral HealthFaculty of DentistryFaculty of DentistryFaculty of DentistryFaculty of DentistryMissouri School of Dentistry and Oral HealthMissouri School of Dentistry and Oral HealthDepartment of Diagnostic SciencesMalignancies of salivary gland origin are rare in children. Mucoepidermoid carcinoma (MEC) is the most common histologic type of salivary gland neoplasm in pediatrics. We report a rare case of parotid MEC in a 20-month-old female patient. The tumor was composed of nests of epidermoid cells with nuclei appearing vesicular, pleomorphic, and hyperchromatic with an admixture of mucous cells and cystic spaces within a prominent connective tissue stroma. Immunohistochemically, the epidermoid cells showed cytokeratin 7 and P63 positivity, and mucous cells were positive for mucicarmine. Molecularly, this case was positive for MAML2 rearrangement by FISH. To our knowledge, this is one of the youngest cases of MEC of the parotid gland reported in the English literature.http://dx.doi.org/10.1155/2022/8749836 |
| spellingShingle | Adepitan A. Owosho Abiodun S. Olatunji Adewale F. Adejobi Olawumi A. Fatusi Toluwaniyin Okunade Kelly Maddux Justin Shaw Kurt F. Summersgill MAML2-Rearranged Mucoepidermoid Carcinoma of the Parotid Gland: A Report in a 20-Month-Old Toddler Case Reports in Dentistry |
| title | MAML2-Rearranged Mucoepidermoid Carcinoma of the Parotid Gland: A Report in a 20-Month-Old Toddler |
| title_full | MAML2-Rearranged Mucoepidermoid Carcinoma of the Parotid Gland: A Report in a 20-Month-Old Toddler |
| title_fullStr | MAML2-Rearranged Mucoepidermoid Carcinoma of the Parotid Gland: A Report in a 20-Month-Old Toddler |
| title_full_unstemmed | MAML2-Rearranged Mucoepidermoid Carcinoma of the Parotid Gland: A Report in a 20-Month-Old Toddler |
| title_short | MAML2-Rearranged Mucoepidermoid Carcinoma of the Parotid Gland: A Report in a 20-Month-Old Toddler |
| title_sort | maml2 rearranged mucoepidermoid carcinoma of the parotid gland a report in a 20 month old toddler |
| url | http://dx.doi.org/10.1155/2022/8749836 |
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