Diagnostic potential of urinary CX3CL1 for amnestic mild cognitive impairment and Alzheimer’s disease
IntroductionThe role of the chemokine CX3CL1 in the processes of aging and Alzheimer’s disease (AD) pathogenesis is well-established. This study aims to evaluate the diagnostic potential of urinary CX3CL1 levels in distinguishing between AD patients, those experiencing amnestic mild cognitive impair...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1501762/full |
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| author | Yali Xu Yali Xu Jie Zhang Jie Zhang Ying-Ying Shen Wei-Wei Li Bin Li Hai-Ping Cheng Gui-Hua Zeng |
| author_facet | Yali Xu Yali Xu Jie Zhang Jie Zhang Ying-Ying Shen Wei-Wei Li Bin Li Hai-Ping Cheng Gui-Hua Zeng |
| author_sort | Yali Xu |
| collection | DOAJ |
| description | IntroductionThe role of the chemokine CX3CL1 in the processes of aging and Alzheimer’s disease (AD) pathogenesis is well-established. This study aims to evaluate the diagnostic potential of urinary CX3CL1 levels in distinguishing between AD patients, those experiencing amnestic mild cognitive impairment (aMCI), and cognitively normal (CN) individuals.MethodsA cohort comprising 516 CN individuals across various age groups, 102 AD patients, and 65 subjects with aMCI was assembled, alongside 93 age- and sex-matched CN controls. Enzyme-linked immunosorbent assay (ELISA) was utilized to quantify urinary CX3CL1 levels.ResultsUrinary CX3CL1 concentrations exhibited an age-dependent increase and demonstrated a positive correlation with age. Comparatively, AD patients exhibited significantly elevated urinary CX3CL1 levels when contrasted with both the CN controls and the aMCI cohort. Conversely, aMCI patients displayed urinary CX3CL1 levels that were notably reduced in comparison to both the AD and CN groups.ConclusionUrinary CX3CL1 levels correlate with the aging process and may serve as a potential diagnostic biomarker for both amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease (AD). |
| format | Article |
| id | doaj-art-a0a371ce84a84add9cbbb891f0cbaa5b |
| institution | Kabale University |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-a0a371ce84a84add9cbbb891f0cbaa5b2025-01-23T06:56:26ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-01-011710.3389/fnagi.2025.15017621501762Diagnostic potential of urinary CX3CL1 for amnestic mild cognitive impairment and Alzheimer’s diseaseYali Xu0Yali Xu1Jie Zhang2Jie Zhang3Ying-Ying Shen4Wei-Wei Li5Bin Li6Hai-Ping Cheng7Gui-Hua Zeng8Department of Geriatrics, Chongqing General Hospital, Chongqing University, Chongqing, ChinaChongqing Clinical Research Centre for Geriatric Diseases, Chongqing, ChinaDepartment of Geriatrics, Chongqing General Hospital, Chongqing University, Chongqing, ChinaChongqing Clinical Research Centre for Geriatric Diseases, Chongqing, ChinaDepartment of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University, Chongqing, ChinaDepartment of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University, Chongqing, ChinaDepartment of Health Management, Chongqing General Hospital, Chongqing University, Chongqing, ChinaDepartment of Health Management, Chongqing General Hospital, Chongqing University, Chongqing, ChinaDepartment of Neurology and Center for Clinical Neuroscience, Daping Hospital, Army Medical University, Chongqing, ChinaIntroductionThe role of the chemokine CX3CL1 in the processes of aging and Alzheimer’s disease (AD) pathogenesis is well-established. This study aims to evaluate the diagnostic potential of urinary CX3CL1 levels in distinguishing between AD patients, those experiencing amnestic mild cognitive impairment (aMCI), and cognitively normal (CN) individuals.MethodsA cohort comprising 516 CN individuals across various age groups, 102 AD patients, and 65 subjects with aMCI was assembled, alongside 93 age- and sex-matched CN controls. Enzyme-linked immunosorbent assay (ELISA) was utilized to quantify urinary CX3CL1 levels.ResultsUrinary CX3CL1 concentrations exhibited an age-dependent increase and demonstrated a positive correlation with age. Comparatively, AD patients exhibited significantly elevated urinary CX3CL1 levels when contrasted with both the CN controls and the aMCI cohort. Conversely, aMCI patients displayed urinary CX3CL1 levels that were notably reduced in comparison to both the AD and CN groups.ConclusionUrinary CX3CL1 levels correlate with the aging process and may serve as a potential diagnostic biomarker for both amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease (AD).https://www.frontiersin.org/articles/10.3389/fnagi.2025.1501762/fullAlzheimer’s diseaseagingamnestic mild cognitive impairmentbiomarkercognitively normal subjectsCX3CL1 |
| spellingShingle | Yali Xu Yali Xu Jie Zhang Jie Zhang Ying-Ying Shen Wei-Wei Li Bin Li Hai-Ping Cheng Gui-Hua Zeng Diagnostic potential of urinary CX3CL1 for amnestic mild cognitive impairment and Alzheimer’s disease Frontiers in Aging Neuroscience Alzheimer’s disease aging amnestic mild cognitive impairment biomarker cognitively normal subjects CX3CL1 |
| title | Diagnostic potential of urinary CX3CL1 for amnestic mild cognitive impairment and Alzheimer’s disease |
| title_full | Diagnostic potential of urinary CX3CL1 for amnestic mild cognitive impairment and Alzheimer’s disease |
| title_fullStr | Diagnostic potential of urinary CX3CL1 for amnestic mild cognitive impairment and Alzheimer’s disease |
| title_full_unstemmed | Diagnostic potential of urinary CX3CL1 for amnestic mild cognitive impairment and Alzheimer’s disease |
| title_short | Diagnostic potential of urinary CX3CL1 for amnestic mild cognitive impairment and Alzheimer’s disease |
| title_sort | diagnostic potential of urinary cx3cl1 for amnestic mild cognitive impairment and alzheimer s disease |
| topic | Alzheimer’s disease aging amnestic mild cognitive impairment biomarker cognitively normal subjects CX3CL1 |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1501762/full |
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