Downregulation of exosomal miR-let-7e-5p induces macrophage M2 polarization by targeting Rictor/AKT1 signal pathway in brucellosis patients

Downregulation of exosomal miR-let-7e-5p induces macrophage M2 polarization by targeting Rictor/AKT1 signal pathway in brucellosis patients

Abstract Background Numerous studies have demonstrated that exosomal microRNAs (miRNAs) are closely associated with the pathological mechanisms underlying various infectious diseases, including brucellosis. Concurrently, macrophage polarization has been identified as a critical factor in the pathoge...

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Main Authors: Shuling Li, Xiaoyu Zhu, Xuhong Wang, Jintong Jia, Mengsi Chen, Qian Wang, Lingling Wang, Peipei Lu, Bin Luo, Min Yang, Junyao Pan, Yezi Liu, Zhiwei Li
Format: Article
Language:English
Published: BMC 2025-07-01
Series:European Journal of Medical Research
Subjects:
Brucellosis
Exosomes
microRNA
Macrophage polarization
Online Access:https://doi.org/10.1186/s40001-025-02867-y
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