A pragmatic pipeline for drug resistance and lineage identification in Mycobacterium tuberculosis using whole genome sequencing.

A pragmatic pipeline for drug resistance and lineage identification in Mycobacterium tuberculosis using whole genome sequencing.

Delays in accurate diagnosis of drug resistant tuberculosis (DR-TB) can hinder treatment. Whole genome sequencing (WGS) provides more information than standard molecular and phenotypic testing, but commonly used platforms are expensive to implement, and data interpretation requires significant exper...

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Main Authors: Linzy Elton, Alp Aydin, Neil Stoker, Sylvia Rofael, Letícia Muraro Wildner, Jabar Babatunde Pacome Agbo Achimi Abdul, John Tembo, Muzamil Abdel Hamid, Mfoutou Mapanguy Claujens Chastel, Julio Ortiz Canseco, Ronan Doyle, Giovanni Satta, Justin O'Grady, Adam Witney, Francine Ntoumi, Alimuddin Zumla, Timothy D McHugh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLOS Global Public Health
Online Access:https://doi.org/10.1371/journal.pgph.0004099
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https://doi.org/10.1371/journal.pgph.0004099

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