Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients
The spontaneous return of fertility after bone marrow transplantation or heterotopic grafting of cryopreserved ovarian cortical tissue has surprised many, and a possible link with stem cells has been proposed. We have reviewed the available literature on ovarian stem cells in adult mammalian ovaries...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2012/921082 |
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| _version_ | 1832561929128771584 |
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| author | Deepa Bhartiya Kalpana Sriraman Seema Parte |
| author_facet | Deepa Bhartiya Kalpana Sriraman Seema Parte |
| author_sort | Deepa Bhartiya |
| collection | DOAJ |
| description | The spontaneous return of fertility after bone marrow transplantation or heterotopic grafting of cryopreserved ovarian cortical tissue has surprised many, and a possible link with stem cells has been proposed. We have reviewed the available literature on ovarian stem cells in adult mammalian ovaries and presented a model that proposes that the ovary harbors two distinct populations of stem cells, namely, pluripotent, quiescent, very small embryonic-like stem cells (VSELs), and slightly larger “progenitor” ovarian germ stem cells (OGSCs). Besides compromising the somatic niche, oncotherapy destroys OGSCs since, like tumor cells, they are actively dividing; however VSELs persist since they are relatively quiescent. BMT or transplanted ovarian cortical tissue may help rejuvenate the ovarian niche, which possibly supports differentiation of persisting VSELs resulting in neo-oogenesis and follicular development responsible for successful pregnancies. Postnatal oogenesis in mammalian ovary from VSELs may be exploited for fertility restoration in cancer survivors including those who were earlier deprived of gametes and/or gonadal tissue cryopreservation options. |
| format | Article |
| id | doaj-art-a0576d6eeb994597936590ca8e8ef6eb |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-a0576d6eeb994597936590ca8e8ef6eb2025-02-03T01:23:56ZengWileyObstetrics and Gynecology International1687-95891687-95972012-01-01201210.1155/2012/921082921082Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer PatientsDeepa Bhartiya0Kalpana Sriraman1Seema Parte2Stem Cell Biology Department, National Institute for Research in Reproductive Health, Parel, Mumbai 400 012, IndiaStem Cell Biology Department, National Institute for Research in Reproductive Health, Parel, Mumbai 400 012, IndiaStem Cell Biology Department, National Institute for Research in Reproductive Health, Parel, Mumbai 400 012, IndiaThe spontaneous return of fertility after bone marrow transplantation or heterotopic grafting of cryopreserved ovarian cortical tissue has surprised many, and a possible link with stem cells has been proposed. We have reviewed the available literature on ovarian stem cells in adult mammalian ovaries and presented a model that proposes that the ovary harbors two distinct populations of stem cells, namely, pluripotent, quiescent, very small embryonic-like stem cells (VSELs), and slightly larger “progenitor” ovarian germ stem cells (OGSCs). Besides compromising the somatic niche, oncotherapy destroys OGSCs since, like tumor cells, they are actively dividing; however VSELs persist since they are relatively quiescent. BMT or transplanted ovarian cortical tissue may help rejuvenate the ovarian niche, which possibly supports differentiation of persisting VSELs resulting in neo-oogenesis and follicular development responsible for successful pregnancies. Postnatal oogenesis in mammalian ovary from VSELs may be exploited for fertility restoration in cancer survivors including those who were earlier deprived of gametes and/or gonadal tissue cryopreservation options.http://dx.doi.org/10.1155/2012/921082 |
| spellingShingle | Deepa Bhartiya Kalpana Sriraman Seema Parte Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients Obstetrics and Gynecology International |
| title | Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients |
| title_full | Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients |
| title_fullStr | Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients |
| title_full_unstemmed | Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients |
| title_short | Stem Cell Interaction with Somatic Niche May Hold the Key to Fertility Restoration in Cancer Patients |
| title_sort | stem cell interaction with somatic niche may hold the key to fertility restoration in cancer patients |
| url | http://dx.doi.org/10.1155/2012/921082 |
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