Macropinocytosis enhances foamy macrophage formation and cholesterol crystallization to activate NLRP3 inflammasome after spinal cord injury

Macropinocytosis enhances foamy macrophage formation and cholesterol crystallization to activate NLRP3 inflammasome after spinal cord injury

After spinal cord injury (SCI), phagocytes endocytose myelin debris to form foam cells, exacerbating the inflammatory response. It has been previously shown that macrophages become foam cells through the phagocytosis of myelin debris via receptor-dependent mechanisms after SCI. Blocking receptor-med...

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Bibliographic Details
Main Authors: Chenxi Zhang, Shujie Zhao, Zhenfei Huang, Ao Xue, Hao Liu, Siming Dai, Ziyang Zheng, Yin Li, Xiaodong Guo, Jun Gu, Feng Zhang, Fubing Wang, Yongxiang Wang, Xiaohua Zhou, Shujun Zhang, Hanwen Zhang, Jun Shen, Jian Chen, Guoyong Yin
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Redox Biology
Subjects:
Spinal cord injury
Macropinocytosis
Myelin debris
Foamy macrophage
NLRP3 inflammasome
Reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724004476
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