Retinal vascular geometry and its association to silent brain infarction
Abstract Objective To examine the relationship between retinal vascular geometry and silent brain infarction (SBI) in the Chinese population. Methods We conducted a cross-sectional study that retrospectively analyzed the fundus photographs, MRI and other clinical data of 227 SBIs and 227 controls wh...
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2025-01-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-025-03854-x |
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| author | Jing Wang Tingli Chen Jing Wang Xiyun Bian Xiaowei Zhang Xiaolong Yang Xing Qi Yihan Li Haixia Huang Qian Qian Fei Yuan |
| author_facet | Jing Wang Tingli Chen Jing Wang Xiyun Bian Xiaowei Zhang Xiaolong Yang Xing Qi Yihan Li Haixia Huang Qian Qian Fei Yuan |
| author_sort | Jing Wang |
| collection | DOAJ |
| description | Abstract Objective To examine the relationship between retinal vascular geometry and silent brain infarction (SBI) in the Chinese population. Methods We conducted a cross-sectional study that retrospectively analyzed the fundus photographs, MRI and other clinical data of 227 SBIs and 227 controls who visited Shanghai Health And Medical Center for physical examination. The retinal vessel fractal dimension (FD), retinal artery fractal dimension (FDa), retinal vein fractal dimension (FDv), central retinal artery diameter in the region from 0.5 ~ 1.0 disc diameter (DD) from the disc margin (CRAEB), central retinal artery diameter in the region from 1.0 ~ 2.0 DD from the disc margin (CRAEC), central retinal vein diameter in the region from 0.5 ~ 1.0 DD from the disc margin (CRVEB), central retinal vein diameter in the region from 1.0 ~ 2.0 DD from the disc margin (CRVEC), retinal arteriovenous diameter ratio in the region from 0.5 ~ 1.0 DD from the disc margin (AVRB), and retinal arteriovenous diameter ratio in the region from 1.0 ~ 2.0 DD from the disc margin (AVRC) were accessed by the Singapore “I” Vessel Assessment (SIVA) software. Results FD, FDa, FDv, CRAEB, CRAEC, CRVEB, CRVEC and AVRB in SBI subjects were 1.25 (1.21–1.28), 1.11 (1.08–1.14), 1.09 (1.06–1.13), 168.78 ± 19.39, 163.55 ± 18.97, 235.77 (222.64-254.08), 224.39 ± 23.29, 0.72 ± 0.06, respectively, significantly lower than those of control subjects [1.30 (1.28–1.32), 1.15 (1.13–1.18), 1.14 (1.12–1.16), 196.81 ± 27.94, 183.81 ± 25.46, 273.03 (247.59–296.30), 249.59 ± 32.03, and 0.73 ± 0.08]. Logistic regression results showed that higher FD (OR, 0.04), FDa (OR, 0.07), FDv (OR, 0.06), CRAEB (OR, 0.02), CRAEC (OR, 0.04), CRVEB (OR, 0.03), CRVEC (OR, 0.06), and AVRB (OR, 0.55) were associated with a lower of SBI. There was no significant difference in AVRC between the two groups. Conclusion Our study shows the association between retinal vascular geometry and SBI, and the results may provide new biomarkers for the early detection of SBI. |
| format | Article |
| id | doaj-art-9fecb4cf36de4762adce2c860195c17a |
| institution | Kabale University |
| issn | 1471-2415 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Ophthalmology |
| spelling | doaj-art-9fecb4cf36de4762adce2c860195c17a2025-01-26T12:21:12ZengBMCBMC Ophthalmology1471-24152025-01-0125111010.1186/s12886-025-03854-xRetinal vascular geometry and its association to silent brain infarctionJing Wang0Tingli Chen1Jing Wang2Xiyun Bian3Xiaowei Zhang4Xiaolong Yang5Xing Qi6Yihan Li7Haixia Huang8Qian Qian9Fei Yuan10Department of Ophthalmology, Zhongshan Hospital, Fudan UniversityDepartment of Ophthalmology, Shanghai Health And Medical CenterDepartment of Ophthalmology, Shanghai Health And Medical CenterDepartment of Ophthalmology, Shanghai Health And Medical CenterDepartment of Nursing, Shanghai Health And Medical CenterDepartment of Ophthalmology, Shanghai Health And Medical CenterDepartment of Otolaryngology, Shanghai Health And Medical CenterDepartment of Otolaryngology, Shanghai Health And Medical CenterDepartment of Radiology, Shanghai Health And Medical CenterDepartment of Ophthalmology, Future Vision Shanghai Anrong Eye ClinicDepartment of Ophthalmology, Zhongshan Hospital, Fudan UniversityAbstract Objective To examine the relationship between retinal vascular geometry and silent brain infarction (SBI) in the Chinese population. Methods We conducted a cross-sectional study that retrospectively analyzed the fundus photographs, MRI and other clinical data of 227 SBIs and 227 controls who visited Shanghai Health And Medical Center for physical examination. The retinal vessel fractal dimension (FD), retinal artery fractal dimension (FDa), retinal vein fractal dimension (FDv), central retinal artery diameter in the region from 0.5 ~ 1.0 disc diameter (DD) from the disc margin (CRAEB), central retinal artery diameter in the region from 1.0 ~ 2.0 DD from the disc margin (CRAEC), central retinal vein diameter in the region from 0.5 ~ 1.0 DD from the disc margin (CRVEB), central retinal vein diameter in the region from 1.0 ~ 2.0 DD from the disc margin (CRVEC), retinal arteriovenous diameter ratio in the region from 0.5 ~ 1.0 DD from the disc margin (AVRB), and retinal arteriovenous diameter ratio in the region from 1.0 ~ 2.0 DD from the disc margin (AVRC) were accessed by the Singapore “I” Vessel Assessment (SIVA) software. Results FD, FDa, FDv, CRAEB, CRAEC, CRVEB, CRVEC and AVRB in SBI subjects were 1.25 (1.21–1.28), 1.11 (1.08–1.14), 1.09 (1.06–1.13), 168.78 ± 19.39, 163.55 ± 18.97, 235.77 (222.64-254.08), 224.39 ± 23.29, 0.72 ± 0.06, respectively, significantly lower than those of control subjects [1.30 (1.28–1.32), 1.15 (1.13–1.18), 1.14 (1.12–1.16), 196.81 ± 27.94, 183.81 ± 25.46, 273.03 (247.59–296.30), 249.59 ± 32.03, and 0.73 ± 0.08]. Logistic regression results showed that higher FD (OR, 0.04), FDa (OR, 0.07), FDv (OR, 0.06), CRAEB (OR, 0.02), CRAEC (OR, 0.04), CRVEB (OR, 0.03), CRVEC (OR, 0.06), and AVRB (OR, 0.55) were associated with a lower of SBI. There was no significant difference in AVRC between the two groups. Conclusion Our study shows the association between retinal vascular geometry and SBI, and the results may provide new biomarkers for the early detection of SBI.https://doi.org/10.1186/s12886-025-03854-xSilent brain infarctionRetinal vascular geometryFractal dimension |
| spellingShingle | Jing Wang Tingli Chen Jing Wang Xiyun Bian Xiaowei Zhang Xiaolong Yang Xing Qi Yihan Li Haixia Huang Qian Qian Fei Yuan Retinal vascular geometry and its association to silent brain infarction BMC Ophthalmology Silent brain infarction Retinal vascular geometry Fractal dimension |
| title | Retinal vascular geometry and its association to silent brain infarction |
| title_full | Retinal vascular geometry and its association to silent brain infarction |
| title_fullStr | Retinal vascular geometry and its association to silent brain infarction |
| title_full_unstemmed | Retinal vascular geometry and its association to silent brain infarction |
| title_short | Retinal vascular geometry and its association to silent brain infarction |
| title_sort | retinal vascular geometry and its association to silent brain infarction |
| topic | Silent brain infarction Retinal vascular geometry Fractal dimension |
| url | https://doi.org/10.1186/s12886-025-03854-x |
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